Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis

Publikation

Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis

Wissenschaftlicher Artikel/Review - 01.08.2007

Chtioui Haithem, Semela David, Ledermann Monika, Zimmermann Arthur, Dufour Jean-François

Zitation

Chtioui H, Semela D, Ledermann M, Zimmermann A, Dufour J. Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis. Liver Int 2007; 27:764-71.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Liver Int 2007; 27

Veröffentlichungsdatum

01.08.2007

ISSN (Druck)

1478-3223

Seiten

764-71

Kurzbeschreibung/Zielsetzung

Nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver (NAFL) have a different prognosis and should be dealt with differently. The pathogenesis of NASH implicates the overexpression of cytochrome P450 2E1 (CYP2E1). We investigated whether the noninvasive determination of CYP2E1 activity could replace a liver biopsy in order to differentiate NASH from NAFL.