Publikation

Interferon and cytokine responses to SARS-coronavirus infection

Wissenschaftlicher Artikel/Review - 01.04.2008

Bereiche
PubMed
DOI

Zitation
Thiel V, Weber F. Interferon and cytokine responses to SARS-coronavirus infection. Cytokine & growth factor reviews 2008; 19:121-32.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Cytokine & growth factor reviews 2008; 19
Veröffentlichungsdatum
01.04.2008
ISSN (Druck)
1359-6101
Seiten
121-32
Kurzbeschreibung/Zielsetzung

The sudden emergence of severe acute respiratory syndrome (SARS) has boosted research on innate immune responses to coronaviruses. It is now well established that the causative agent, a newly identified coronavirus termed SARS-CoV, employs multiple passive and active mechanisms to avoid induction of the antiviral type I interferons in tissue cells. By contrast, chemokines such as IP-10 or IL-8 are strongly upregulated. The imbalance in the IFN response is thought to contribute to the establishment of viremia early in infection, whereas the production of chemokines by infected organs may be responsible for (i) massive immune cell infiltrations found in the lungs of SARS victims, and (ii) the dysregulation of adaptive immunity. Here, we will review the most recent findings on the interaction of SARS-CoV and related Coronaviridae members with the type I interferon and cytokine responses and discuss implications for pathogenesis and therapy.