Evaluation of radiation-related invasion in primary patient-derived glioma cells and validation with established cell lines: impact of different radiation qualities with differing LET.

Publikation

Evaluation of radiation-related invasion in primary patient-derived glioma cells and validation with established cell lines: impact of different radiation qualities with differing LET.

Wissenschaftlicher Artikel/Review - 08.06.2018

Wank M, Schilling D, Reindl J, Meyer Benedikt J, Gempt Jens, Motov Stefan, Alexander F, Wilkens J J, Schlegel Jürgen, Schmid T, Combs Stephanie E

Zitation

Wank M, Schilling D, Reindl J, Meyer B, Gempt J, Motov S, Alexander F, Wilkens J, Schlegel J, Schmid T, Combs S. Evaluation of radiation-related invasion in primary patient-derived glioma cells and validation with established cell lines: impact of different radiation qualities with differing LET. J Neurooncol 2018; 139:583-590.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Neurooncol 2018; 139

Veröffentlichungsdatum

08.06.2018

eISSN (Online)

1573-7373

Seiten

583-590

Kurzbeschreibung/Zielsetzung

Glioblastoma multiforme (GBM) is the most common primary brain tumor and has a very poor overall prognosis. Multimodal treatment is still inefficient and one main reason is the invasive nature of GBM cells, enabling the tumor cells to escape from the treatment area causing tumor progression. This experimental study describes the effect of low- and high-LET irradiation on the invasion of primary GBM cells with a validation in established cell systems.