Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.

Publikation

Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.

Wissenschaftlicher Artikel/Review - 12.07.2023

D'Rozario Joshua, Knoblich Konstantin, Lütge Mechthild, Pérez Shibayama Christian Ivan, Cheng Hung-Wei, Alexandre Yannick O, Roberts David J, Campos Joana, Dutton Emma E, Suliman Muath, Denton Alice E, Turley Shannon J, Boyd Richard L, Mueller Scott N, Ludewig Burkhard, Heng Tracy S P, Fletcher Anne L

Zitation

D'Rozario J, Knoblich K, Lütge M, Pérez Shibayama C, Cheng H, Alexandre Y, Roberts D, Campos J, Dutton E, Suliman M, Denton A, Turley S, Boyd R, Mueller S, Ludewig B, Heng T, Fletcher A. Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages. Eur J Immunol 2023; 53:e2250355.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Eur J Immunol 2023; 53

Veröffentlichungsdatum

12.07.2023

eISSN (Online)

1521-4141

Seiten

e2250355

Kurzbeschreibung/Zielsetzung

The lymph node (LN) is home to resident macrophage populations that are essential for immune function and homeostasis, but key factors controlling this niche are undefined. Here, we show that fibroblastic reticular cells (FRCs) are an essential component of the LN macrophage niche. Genetic ablation of FRCs caused rapid loss of macrophages and monocytes from LNs across two in vivo models. Macrophages co-localized with FRCs in human LNs, and murine single-cell RNA-sequencing revealed that FRC subsets broadly expressed master macrophage regulator CSF1. Functional assays containing purified FRCs and monocytes showed that CSF1R signaling was sufficient to support macrophage development. These effects were conserved between mouse and human systems. These data indicate an important role for FRCs in maintaining the LN parenchymal macrophage niche.