Protocolised early de-resuscitation in septic shock (REDUCE): protocol for a randomised controlled multicentre feasibility trial.

Publikation

Protocolised early de-resuscitation in septic shock (REDUCE): protocol for a randomised controlled multicentre feasibility trial.

Wissenschaftlicher Artikel/Review - 21.09.2023

Messmer Anna, Pietsch Urs, Siegemund Martin, Buehler Philipp K, Waskowski Jan, Müller-Nurasyid Martina, Uehlinger Dominik E, Hollinger Alexa, Filipovic Miodrag, Berger David, Schefold Joerg C, Pfortmueller Carmen A

Zitation

Messmer A, Pietsch U, Siegemund M, Buehler P, Waskowski J, Müller-Nurasyid M, Uehlinger D, Hollinger A, Filipovic M, Berger D, Schefold J, Pfortmueller C. Protocolised early de-resuscitation in septic shock (REDUCE): protocol for a randomised controlled multicentre feasibility trial. BMJ Open 2023; 13:e074847.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

BMJ Open 2023; 13

Veröffentlichungsdatum

21.09.2023

eISSN (Online)

2044-6055

Seiten

e074847

Kurzbeschreibung/Zielsetzung

Fluid overload is associated with excess mortality in septic shock. Current approaches to reduce fluid overload include restrictive administration of fluid or active removal of accumulated fluid. However, evidence on active fluid removal is scarce. The aim of this study is to assess the efficacy and feasibility of an early de-resuscitation protocol in patients with septic shock.