Publikation

Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST).

Wissenschaftlicher Artikel/Review - 19.05.2022

Bereiche
PubMed
DOI
Kontakt

Zitation
Eltoft A, Wilsgaard T, Roaldsen M, Søyland M, Lundström E, Petersson J, Indredavik B, Putaala J, Christensen H, Kõrv J, Jatužis D, Engelter S, De Marchis G, Werring D, Robinson T, Tveiten A, Mathiesen E. Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST). Trials 2022; 23:421.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Trials 2022; 23
Veröffentlichungsdatum
19.05.2022
eISSN (Online)
1745-6215
Seiten
421
Kurzbeschreibung/Zielsetzung

Patients with wake-up ischemic stroke are frequently excluded from thrombolytic treatment due to unknown symptom onset time and limited availability of advanced imaging modalities. The Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST) is a randomized controlled trial of intravenous tenecteplase 0.25 mg/kg and standard care versus standard care alone (no thrombolysis) in patients who wake up with acute ischemic stroke and can be treated within 4.5 h of wakening based on non-contrast CT findings.