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The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury.
Wissenschaftlicher Artikel/Review - 18.07.2022
Akeret Kevin, Buzzi Raphael, Saxenhofer Moritz, Bieri Kathrin, Chiavi Deborah, Thomson Bart R, Grüttner-Durmaz Manuela, Schwendinger Nina, Humar Rok, Regli Luca, van Doormaal Tristan P C, Held Ulrike, Keller Emanuela, Hugelshofer Michael, Schaer Dominik J, Hostettler Isabel C
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Preclinical studies provided a strong rationale for a pathophysiological link between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain injury after subarachnoid hemorrhage (SAH-SBI). In a single-center prospective observational clinical study, external ventricular drain (EVD) based CSF-Hb proved to be a promising biomarker to monitor for SAH-SBI. The primary objective of the HeMoVal study is to prospectively validate the association between EVD based CSF-Hb and SAH-SBI during the first 14 days post-SAH. Secondary objectives include the assessment of the discrimination ability of EVD based CSF-Hb for SAH-SBI and the definition of a clinically relevant range of EVD based CSF-Hb toxicity. In addition, lumbar drain (LD) based CSF-Hb will be assessed for its association with and discrimination ability for SAH-SBI.