Publikation
High-dose vitamin D substitution in patients with COVID-19: study protocol for a randomized, double-blind, placebo-controlled, multi-center study-VitCov Trial.
Wissenschaftlicher Artikel/Review - 04.02.2022
Jaun Fabienne, Boesing Maria, Lüthi-Corridori Giorgia, Abig Kristin, Makhdoomi Anja, Bloch Nando, Lins Christina, Raess Andrea, Grillmayr Victoria, Haas Philippe, Schuetz Philipp, Gabutti Luca, Muser Jürgen, Leuppi-Taegtmeyer Anne Barbara, Giezendanner Stéphanie, Brändle Michael, Leuppi Jörg D
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The coronavirus disease 19 (COVID-19) pandemic has caused millions of deaths, and new treatments are urgently needed. Factors associated with a worse COVID-19 prognosis include old age (> 65 years), ethnicity, male sex, obesity, and people with comorbidities. Furthermore, vitamin D deficiency was reported as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. According to a recent clinical case series, vitamin D deficiency is a modifiable risk factor, which has the prospect of reducing hospital stay, intensive care, and fatal outcomes. Vitamin D has potent immunomodulatory properties, and its supplementation might improve important outcomes in critically ill and vitamin D-deficient COVID-19 patients. Despite the evidence that supports an association between vitamin D deficiency and COVID-19 severity, there is uncertainty about the direct link. Therefore, the aim of the trial is to assess if high-dose vitamin D supplementation has a therapeutic effect in vitamin D-deficient patients with COVID-19.