Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues.

Publikation

Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues.

Wissenschaftlicher Artikel/Review - 18.01.2022

Kubiniok Peter, Marcu Ana, Bichmann Leon, Kuchenbecker Leon, Schuster Heiko, Hamelin David J, Duquette Jérôme D, Kovalchik Kevin A, Wessling Laura, Kohlbacher Oliver, Rammensee Hans-Georg, Neidert Marian C, Sirois Isabelle, Caron Etienne

Zitation

Kubiniok P, Marcu A, Bichmann L, Kuchenbecker L, Schuster H, Hamelin D, Duquette J, Kovalchik K, Wessling L, Kohlbacher O, Rammensee H, Neidert M, Sirois I, Caron E. Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues. iScience 2022; 25:103768.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

iScience 2022; 25

Veröffentlichungsdatum

18.01.2022

eISSN (Online)

2589-0042

Seiten

103768

Kurzbeschreibung/Zielsetzung

Understanding the molecular principles that govern the composition of the MHC-I immunopeptidome across different primary tissues is fundamentally important to predict how T cells respond in different contexts . Here, we performed a global analysis of the MHC-I immunopeptidome from 29 to 19 primary human and mouse tissues, respectively. First, we observed that different HLA-A, HLA-B, and HLA-C allotypes do not contribute evenly to the global composition of the MHC-I immunopeptidome across multiple human tissues. Second, we found that tissue-specific and housekeeping MHC-I peptides share very distinct properties. Third, we discovered that proteins that are evolutionarily hyperconserved represent the primary source of the MHC-I immunopeptidome at the organism-wide scale. Fourth, we uncovered new components of the antigen processing and presentation network, including the carboxypeptidases CPE, CNDP1/2, and CPVL. Together, this study opens up new avenues toward a system-wide understanding of antigen presentation across mammalian species.