Publikation

Vaccination with Designed Neopeptides Induces Intratumoral, Cross-reactive CD4+ T-cell Responses in Glioblastoma.

Wissenschaftlicher Artikel/Review - 15.12.2022

Bereiche
PubMed
DOI
Kontakt

Zitation
Wang J, Weiss T, Neidert M, Toussaint N, Naghavian R, Sellés Moreno C, Foege M, Tomas Ojer P, Medici G, Jelcic I, Schulz D, Rushing E, Dettwiler S, Schrörs B, Shin J, McKay R, Wu C, Lutterotti A, Sospedra M, Moch H, Greiner E, Bodenmiller B, Regli L, Weller M, Roth P, Martin R. Vaccination with Designed Neopeptides Induces Intratumoral, Cross-reactive CD4+ T-cell Responses in Glioblastoma. Clin Cancer Res 2022; 28:5368-5382.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Clin Cancer Res 2022; 28
Veröffentlichungsdatum
15.12.2022
eISSN (Online)
1557-3265
Seiten
5368-5382
Kurzbeschreibung/Zielsetzung

The low mutational load of some cancers is considered one reason for the difficulty to develop effective tumor vaccines. To overcome this problem, we developed a strategy to design neopeptides through single amino acid mutations to enhance their immunogenicity.