Publikation

Retransplanting a previously transplanted kidney: A safe strategy in times of organ shortage?

Wissenschaftlicher Artikel/Review - 04.12.2021

Bereiche
PubMed
DOI

Zitation
Karakizlis H, Padberg W, Nitschke M, Berlakovich G, Lorf T, Vogelaar S, Askevold I, Boide P, van Rosmalen M, Weimer R. Retransplanting a previously transplanted kidney: A safe strategy in times of organ shortage?. Clin Transplant 2021:e14554.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Clin Transplant 2021
Veröffentlichungsdatum
04.12.2021
eISSN (Online)
1399-0012
Seiten
e14554
Kurzbeschreibung/Zielsetzung

BACKGROUND
The shortage of organs for transplantation remains a global problem. The retransplantation of a previously transplanted kidney might be a possibility to expand the pool of donors. We provide our experience with the successful reuse of transplanted kidneys in the Eurotransplant region.

METHODS
A query in the Eurotransplant database was performed between January 1, 1995 and December 31, 2015, to find kidney donors who themselves had previously received a kidney graft.

RESULTS
Nine out of a total of 68,554 allocated kidneys had previously been transplanted. Four of these kidneys were transplanted once again. The mean interval between the first transplant and retransplantation was 1689±1682 days (SD; range 55-5,333 days). At the time of the first transplantation the mean serum creatinine of the donors was 1.0 mg/dl (.6-1.3 mg/dl) and at the second transplantation 1.4 mg/dl (.8-1.5 mg/dl). The mean graft survival in the first recipient was 50 months (2-110 months) and in the second recipient 111 months (40-215 months).

CONCLUSION
Transplantation of a previously transplanted kidney may successfully be performed with well-preserved graft function and long-term graft survival, even if the first transplantation was performed a long time ago. Such organs should be considered even for younger recipients in carefully selected cases.