Publikation
Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation
Wissenschaftlicher Artikel/Review - 01.08.2008
Collaud Stéphane, Robert John H, Martin Pierre-Yves, Rizzoli René, Myers Patrick O, Binet Françoise-Isabelle, Marangon Nicola, Clerici Thomas, Trombetti Andrea, Staub-Zähner Tania, Triponez Frederic
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BACKGROUND: Few studies have reported changes of bone mineral density (BMD) after parathyroidectomy in patients with persistent hyperparathyroidism after renal transplantation (3 HPT). PATIENTS AND METHODS: We retrospectively analyzed 14 patients who underwent successful parathyroidectomy for 3 HPT and who had available BMD data before and after parathyroidectomy. RESULTS: Median follow-up time was 26 months (IQR: 16.8-40.2). Serum calcium levels decreased significantly after parathyroidectomy (2.32 +/- 0.09 versus 2.66 +/- 0.16 mmol/l; p < 0.01), as did PTH levels (5.1 +/- 3.0 versus 27.8 +/- 23.7 pmol/l; p < 0.01). Nine patients (64%) had a steroid-free immunosuppression at follow-up. Mean increase in BMD was 9.5 +/- 8.0% for the spine and 9.5 +/- 7.9% for the hip (p < 0.01 for both sites). Patients with osteoporosis (T-score