Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer? - Publikation

Publikation

Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer?

Wissenschaftlicher Artikel/Review - 18.12.2017

Polasik Arkadius, Janni Wolfgang, Huober Jens, Müller Volkmar, Schneeweiss Andreas, Fasching Peter A, Hartkopf Andreas, Rack Brigitte, Friedl Thomas W P, De Gregorio Amelie, Schochter Fabienne, Tzschaschel Marie, Fehm Tanja

Zitation

Polasik A, Janni W, Huober J, Müller V, Schneeweiss A, Fasching P, Hartkopf A, Rack B, Friedl T, De Gregorio A, Schochter F, Tzschaschel M, Fehm T. Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer?. Geburtshilfe Frauenheilkd 2017; 77:1291-1298.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Geburtshilfe Frauenheilkd 2017; 77

Veröffentlichungsdatum

18.12.2017

ISSN (Druck)

0016-5751

Seiten

1291-1298

Kurzbeschreibung/Zielsetzung

Dissemination of tumour cells and the development of solid metastases occurs via blood vessels and lymphatics. Circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) can be detected in venous blood in patients with early and metastatic breast cancer, and their prognostic relevance has been demonstrated on numerous occasions. Repeated testing for CTCs and ctDNA, or regular so-called "liquid biopsy", can be performed easily at any stage during the course of disease. Additional molecular analysis allows definition of tumour characteristics and heterogeneity that may be associated with treatment resistance. This in turn makes personalised, targeted treatments possible that may achieve both improved overall survival and quality of life.