Projects
Search from 1166 projects:
1166 Project(s)
PROtective ventilation with FLOW–controlled ventilation to improve postoperative pulmonary outcome after ROBOT–assisted laparoscopic surgery – an international multicenter pilot randomized clinical trial.
Dec 31, 2024In einer internationalen, multizentrischen, randomisierten klinischen Pilotstudie wird die intraoperative flusskontrollierte Beatmung (FCV) mit der druckkontrollierten Beatmung (PCV) bei Patienten verglichen, die für eine roboterassistierte laparosko...
Clinical Studies - Dec 31, 2024 - Mar 31, 2025
Scheduled
Project leader: Yurttas Timur, Lüdi Markus
Assessment of Torque Teno Virus (TTV) viral load as marker for baseline immunity in healthcare workers
Dec 2, 2024This project will retrospectively assess the association of SARS-CoV-2 vaccination status with TTV viral loads in a cohort of healthcare workers and correlation with susceptibility to respiratory infections, determined by total number of influenza-li...
Clinical Studies - Dec 2, 2024 - Oct 31, 2025
Scheduled
Project leader: Kohler Philipp
Members: Kuster Stefan, Kahlert Christian, Grässli Fabian
SWISS TAVI
Nov 4, 2024Prospective, National, Multi-Center Registry of Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI) in Switzerland (SwissTAVI)
Register - Nov 4, 2024 - Dec 30, 2040
Ongoing
Members: Haager Philipp, Vetsch Susanne, Maeder Micha
Colchicine in Patients at Cardiac Risk undergoing Major Non-Cardiac Surgery: prospective, randomized, triple-blinded, placebo-controlled, multi-centre study
Nov 1, 2024
Clinical Studies - Nov 1, 2024 - Sep 30, 2027
Scheduled
Project leader: Filipovic Miodrag, Yurttas Timur
Members: Klein Carsten, Keller Mirja
Major adverse cardiovascular events in cancer patients during and after treatment with immune checkpoint inhibitors
Nov 1, 2024
Clinical Studies - Nov 1, 2024 - Oct 31, 2027
Scheduled
Project leader: Daetwyler Eveline
Members: Scheler Eva, Kuster Gabriela M, Zippelius Alfred, Rothschild Sacha I
Addition of Darolutamide to first line treatment of mCRPC: a randomized open label phase II trial.
Oct 31, 2024
Clinical Studies - Oct 31, 2024 - Dec 31, 2028
Ongoing
Project leader: Fischer Stefanie
Members: Dei Cas Alissa
AMG 355 20220028
Oct 17, 2024Eine Phase-1-Studie am Menschen zur Bewertung der Sicherheit, Verträglichkeit, Pharmakokinetik und Wirksamkeit von AMG 355 als Monotherapie und in Kombination mit Pembrolizumab bei Patienten mit fortgeschrittenen soliden Tumoren
Clinical Studies - Oct 17, 2024 - Dec 31, 2028
Ongoing
Project leader: Jörger Markus
Members: Donno Monica, Müller Fiona
SAKK 66/22 - Invincible 4 SAKK
Oct 17, 2024Protocol SAKK 66/22: Intratumoral INT230-6 followed by neoadjuvant immunochemotherapy in patients with early triple-negative breast cancer (TNBC). An openlabel randomized two-cohort phase 2 clinical trial. INVINCIBLE-4-SAKK
Clinical Studies - Oct 17, 2024 - Dec 31, 2029
Ongoing
Project leader: Jörger Markus
Members: Dei Cas Alissa, Müller Fiona
A comparison between the Swiss traffic perimetry (Swiss TPT) and the normal G2 strategy in automated perimetry: Observational cohort study
Oct 10, 2024Current Swiss visual requirements for driving are under re-evaluation. The present study aims to optimize visual field evaluation in daily practice to better differentiate between people who are fit to drive and those who are not.
Clinical Studies - Oct 10, 2024 - Oct 31, 2026
Ongoing
Project leader: Todorova Margarita
A multicenter, open-label, randomized, phase 2 study of venetoclax and azacitidine plus cusatuzumab versus venetoclax and azacitidine alone in newly diagnosed AML patients who are not candidates for intensive therapy
Oct 7, 2024
Clinical Studies - Oct 7, 2024 - Oct 9, 2028
Ongoing
Project leader: Schittenhelm Marcus
Members: Dei Cas Alissa
A phase 3 randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of Amyloid Depleter ALXN2220 in adult participants with Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Oct 1, 2024
Clinical Studies - Oct 1, 2024 - Dec 31, 2029
Scheduled
Project leader: Ehl Niklas
Members: Vetsch Susanne
MS201924_0002
Sep 30, 2024An open-label, multicenter, randomized Phase 2 study of the ATR inhibitor tuvusertib in combination with the PARP inhibitor niraparib or the ATM inhibitor lartesertib in participants with BRCA mutant and/or homologous recombination deficiency (HRD) p...
Clinical Studies - Sep 30, 2024 - Sep 30, 2028
Ongoing
Project leader: Huober Jens
Members: Dei Cas Alissa, Müller Fiona
Pulmonary Vein Isolation with Pulsed-Field Ablation with versus without Posterior wall ablation in Patients with Symptomatic Persistent Atrial Fibrillation
Sep 17, 2024A multicentre randomised clinical trial comparing two ablation strategies for the treatment of persistent AF (PVI only or PVI+ posterior wall ablation). IC: persistent AF, (N)OAK EC: atrial interventions, o. atrium >60mm, TAVI, Ml, >NYHA III, LVEF...
Clinical Studies - Sep 17, 2024 - Sep 17, 2027
Ongoing
Project leader: Franzeck Florian M
Members: Meier Jessica, Vetsch Susanne
Humoral immunity and risk factors for Alongshan-virus in healthcare workers from Eastern Switzerland –proposal for a seroepidemiologic analysis
Aug 1, 2024In dieser prospektiven Studie innerhalb der SURPRISE+ Kohorte möchten wir die Seroprävalenz und Serokonversion gegen das Alongshan-Virus (ALSV). ALSV ist ein Flavivirus, welches ein FSME-ähnliches Krankheitsbild auslösen kann. Das Virus wird häufig i...
Clinical Studies - Aug 1, 2024 - Feb 28, 2026
Ongoing
Project leader: Kohler Philipp
Members: Frischknecht Manuel, Kuster Stefan, Kahlert Christian
Textile ECG electrodes for long-term monitoring (Tex3CG)
Jul 1, 2024The objective of this project is to evaluate and compare the signal quality of electrocardiogram (ECG) signals acquired by adhesive textile ECG electrodes (Tex) using adhesive gel electrodes (Gel) as a reference system.
Clinical Studies - Jul 1, 2024 - Dec 31, 2024
Ongoing
Project leader: Annaheim Simon, Ammann Peter
Members: Meier Jessica
Hemodynamic characteristics of bendopnea – pathophysiological basis of a novel symptom in heart failure patients
Jul 1, 2024The present project has several objectives. Our main goal is to evaluate the hemodynamic characteristics in particular the mean pulmonary artery wedge pressure (mPAWP) of patients with versus without bendopnea and those with high (supramedian) vers...
Clinical Studies - Jul 1, 2024 - Jun 30, 2026
Ongoing
Project leader: Maeder Micha
Members: Schneider Irene
Influence of COVID-19 Pandemic on the Incidence of Acute Otitis Media with Complications: A Retrospective Cohort Study at a Tertiary Care Hospital
Jul 1, 2024Acute otitis media (AOM) is typically a condition that resolves without long-term sequelae. However, it may be associated with complications. These can range from local complications such as involvement of the inner ear, potentially leading to persis...
Clinical Studies - Jul 1, 2024 - Jul 1, 2025
Ongoing
Project leader: Stöckli Sandro
Members: Albrich Werner, Menegotto Richard
Metabolic acidosis: changes in bone mineral metabolism after bicarbonate treatment in kidney transplantation
Jul 1, 2024Metabolic acidosis (MA) is a frequent complication in kidney transplantation (KTx). Chronic MA after KTx is associated with impaired mineral metabolism and growth retardation in children. After transplantation, skeletal health may be particularly sus...
Clinical Studies - Jul 1, 2024 - Dec 31, 2025
Ongoing
Members: Ritter Alexander, Wagner Carsten A, Mohebbi Nilufar
A first-in-human, open-label, multicenter Phase l/ll study to evaluate the safety and anti-tumor activity of ANV600 as single agent and in combination with pembrolizumab in participants with advanced solid tumors (EXPAND-1)
Jun 13, 2024
Clinical Studies - Jun 13, 2024 - Dec 31, 2028
Ongoing
Project leader: Jörger Markus
Members: Sennhauser Andrina, Müller Fiona
Shunt-dependency after aneurysmal subarachnoid haemorrhage – the role of early hyperglycaemia in cerebro-spinal fluid and blood
May 26, 2024Several factors influence morbidity after aneurysmal subarachnoid haemorrhage (aSAH) and therefore also functional outcome. One of these factors is hydrocephalus (HCP) which, in case of unsuccessful weaning from an extraventricular drain (EVD) can le...
Clinical Studies - May 26, 2024 - Sep 1, 2027
Ongoing
Project leader: Hostettler Isabel
Members: Wiebe Lauren, Pietsch Urs, Klein Carsten, Keller Mirja, Kälin Vincens, Yildiz Yesim