Projects

In einer internationalen, multizentrischen, randomisierten klinischen Pilotstudie wird die intraoperative flusskontrollierte Beatmung (FCV) mit der druckkontrollierten Beatmung (PCV) bei Patienten verglichen, die für eine roboterassistierte laparosko...

Clinical Studies - Dec 31, 2024 - Mar 31, 2025

Scheduled

Project leader: Yurttas Timur, Lüdi Markus

This project will retrospectively assess the association of SARS-CoV-2 vaccination status with TTV viral loads in a cohort of healthcare workers and correlation with susceptibility to respiratory infections, determined by total number of influenza-li...

Clinical Studies - Dec 2, 2024 - Oct 31, 2025

Scheduled

Project leader: Kohler Philipp
Members: Kuster Stefan, Kahlert Christian, Grässli Fabian

Prospective, National, Multi-Center Registry of Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI) in Switzerland (SwissTAVI)

Register - Nov 4, 2024 - Dec 30, 2040

Ongoing

Members: Haager Philipp, Vetsch Susanne, Maeder Micha

Clinical Studies - Nov 1, 2024 - Sep 30, 2027

Scheduled

Project leader: Filipovic Miodrag, Yurttas Timur
Members: Klein Carsten, Keller Mirja

Clinical Studies - Nov 1, 2024 - Oct 31, 2027

Scheduled

Project leader: Daetwyler Eveline
Members: Scheler Eva, Kuster Gabriela M, Zippelius Alfred, Rothschild Sacha I

Eine Phase-1-Studie am Menschen zur Bewertung der Sicherheit, Verträglichkeit, Pharmakokinetik und Wirksamkeit von AMG 355 als Monotherapie und in Kombination mit Pembrolizumab bei Patienten mit fortgeschrittenen soliden Tumoren

Clinical Studies - Oct 17, 2024 - Dec 31, 2028

Ongoing

Project leader: Jörger Markus
Members: Donno Monica, Müller Fiona

Protocol SAKK 66/22: Intratumoral INT230-6 followed by neoadjuvant immunochemotherapy in patients with early triple-negative breast cancer (TNBC). An openlabel randomized two-cohort phase 2 clinical trial. INVINCIBLE-4-SAKK

Clinical Studies - Oct 17, 2024 - Dec 31, 2029

Ongoing

Project leader: Jörger Markus
Members: Dei Cas Alissa, Müller Fiona

Current Swiss visual requirements for driving are under re-evaluation. The present study aims to optimize visual field evaluation in daily practice to better differentiate between people who are fit to drive and those who are not.

Clinical Studies - Oct 10, 2024 - Oct 31, 2026

Ongoing

Project leader: Todorova Margarita

Clinical Studies - Oct 7, 2024 - Oct 9, 2028

Ongoing

Project leader: Schittenhelm Marcus
Members: Dei Cas Alissa

Clinical Studies - Oct 1, 2024 - Dec 31, 2029

Scheduled

Project leader: Ehl Niklas
Members: Vetsch Susanne

An open-label, multicenter, randomized Phase 2 study of the ATR inhibitor tuvusertib in combination with the PARP inhibitor niraparib or the ATM inhibitor lartesertib in participants with BRCA mutant and/or homologous recombination deficiency (HRD) p...

Clinical Studies - Sep 30, 2024 - Sep 30, 2028

Ongoing

Project leader: Huober Jens
Members: Dei Cas Alissa, Müller Fiona

In dieser prospektiven Studie innerhalb der SURPRISE+ Kohorte möchten wir die Seroprävalenz und Serokonversion gegen das Alongshan-Virus (ALSV). ALSV ist ein Flavivirus, welches ein FSME-ähnliches Krankheitsbild auslösen kann. Das Virus wird häufig i...

Clinical Studies - Aug 1, 2024 - Feb 28, 2026

Ongoing

Project leader: Kohler Philipp
Members: Frischknecht Manuel, Kuster Stefan, Kahlert Christian

The objective of this project is to evaluate and compare the signal quality of electrocardiogram (ECG) signals acquired by adhesive textile ECG electrodes (Tex) using adhesive gel electrodes (Gel) as a reference system.

Clinical Studies - Jul 1, 2024 - Dec 31, 2024

Ongoing

Project leader: Annaheim Simon, Ammann Peter
Members: Meier Jessica

The present project has several objectives. Our main goal is to evaluate the hemodynamic characteristics in particular the mean pulmonary artery wedge pressure (mPAWP) of patients with versus without bendopnea and those with high (supramedian) vers...

Clinical Studies - Jul 1, 2024 - Jun 30, 2026

Ongoing

Project leader: Maeder Micha
Members: Schneider Irene

Acute otitis media (AOM) is typically a condition that resolves without long-term sequelae. However, it may be associated with complications. These can range from local complications such as involvement of the inner ear, potentially leading to persis...

Clinical Studies - Jul 1, 2024 - Jul 1, 2025

Ongoing

Project leader: Stöckli Sandro
Members: Albrich Werner, Menegotto Richard

Metabolic acidosis (MA) is a frequent complication in kidney transplantation (KTx). Chronic MA after KTx is associated with impaired mineral metabolism and growth retardation in children. After transplantation, skeletal health may be particularly sus...

Clinical Studies - Jul 1, 2024 - Dec 31, 2025

Ongoing

Members: Ritter Alexander, Wagner Carsten A, Mohebbi Nilufar

Clinical Studies - Jun 13, 2024 - Dec 31, 2028

Ongoing

Project leader: Jörger Markus
Members: Sennhauser Andrina, Müller Fiona

Several factors influence morbidity after aneurysmal subarachnoid haemorrhage (aSAH) and therefore also functional outcome. One of these factors is hydrocephalus (HCP) which, in case of unsuccessful weaning from an extraventricular drain (EVD) can le...

Clinical Studies - May 26, 2024 - Sep 1, 2027

Ongoing

Project leader: Hostettler Isabel
Members: Wiebe Lauren, Pietsch Urs, Klein Carsten, Keller Mirja, Kälin Vincens, Yildiz Yesim

To evaluate the continued safety and performance of the Reva Fantom Sirolismus-Eluting Bioresorbable Coronary Scaffold in nativ coronary arteries that includes incorporation of a deformable expansion technologgy and an enhanced scaffold material (Tyr...

Clinical Studies - May 6, 2024 - Jun 30, 2030

Ongoing

Project leader: Rigger Johannes
Members: Fink Karin, Schneider Irene

Consumption of so-called novel psychoactive substances (e.g. “synthetic opioids” and “synthetic cannabinoids”) is a growing global health threat. Due to the rapid market dynamics of the new drugs of abuse market current analytical methods cannot keep...

Fundamental Research - May 1, 2024 - Apr 30, 2025

Scheduled

Project leader: Moosmann Björn