CATCH - Cascade genetic testing of familial hypercholesterolemia: the CATCH multicenter randomized controlled trial - Projekt

Projekt

CATCH - Cascade genetic testing of familial hypercholesterolemia: the CATCH multicenter randomized controlled trial

Abgeschlossen · 2020 bis 2024

Rickli Hans, Vetsch Susanne, Schneider Irene

Art

Klinische Forschung

Reichweite

Multizentrisch, KSSG als teilnehmendes Zentrum

Bereiche

Kardiologie

Status

Abgeschlossen

Start

2020

Ende

2024

Finanzierungsart

Andere

Studiendesign

Multicenter open-label randomized controlled trial, with 2x 2 arms. Index cases with clinical criteria for FH will be separated into two groups before randomization, based on the result of the genetic test, either positive or negative for a mongenic mutation in one of the three genes causing FH. In each of these two groups, a randomization procedure will allocate index cases and their family member into the intervention arm or the control arm to evaluate the best method to contact at-risk relatives and perform cascade screening. In the intervention arm, the index case will be actively supported by a web-based centralized service to initiate contact with their first-degree relatives. In the control arm or “usual care arm”, the index case will be encouraged to initiated contact with their first-degree relatives, but without additional support. The presence or absence of a monogenic mutation in the index case will determine the screening test used for cascade screening of relatives, either genetic or lipid test.

Schlagwörter (Tags)

familial hypercholesterolemia, genetic testing

Webseite

https://catch.unisante.ch/

Kurzbeschreibung/Zielsetzung

To test in a multicenter open-label randomized controlled trial across Switzerland whether a cascade screening programme for FH, in comparison with usual care, will increase the detection rate of FH within families.

The primary outcome will be the difference in the yield of detection of familial hypercholesterolemia (FH) between arms. The yield of detection is the number of test performed/number of contactable relatives.

Secondary endpoints include the transmission rate of phenotype and genotype into families. After 6 months follow-up, the differences in the use of lipid-lowering drug and change in LDL-cholesterol will be the third endpoint.