CATCH - Cascade genetic testing of familial hypercholesterolemia: the CATCH multicenter randomized controlled trial
Laufend - Rekrutierung – beendet · 2020 bis 2023
Rickli Hans, Vetsch Susanne, Schneider Irene
To test in a multicenter open-label randomized controlled trial across Switzerland whether a cascade screening programme for FH, in comparison with usual care, will increase the detection rate of FH within families.
The primary outcome will be the difference in the yield of detection of familial hypercholesterolemia (FH) between arms. The yield of detection is the number of test performed/number of contactable relatives.
Secondary endpoints include the transmission rate of phenotype and genotype into families. After 6 months follow-up, the differences in the use of lipid-lowering drug and change in LDL-cholesterol will be the third endpoint.