Projekt

ON-TRK: PrOspective Non-interventional study in patients with locally advanced or metastatic TRK fusion cancer treated with larotrectinib

Laufend - Rekrutierung – laufend · 2021 bis 2025

Art
Klinische Forschung
Reichweite
Multizentrisch, KSSG als teilnehmendes Zentrum
Bereiche
Status
Laufend - Rekrutierung – laufend
Start
2021
Ende
2025
Finanzierungsart
Industrie
Label
Anderer Krebs
Kurzbeschreibung/Zielsetzung

TRK fusion cancer is rare but presents as a variety of solid
tumors. Larotrectinib is a highly selective TRK inhibitor
that, in a pooled analysis of patients in phase 1/2 clinical
trials, demonstrated an effective and sustained response in
the majority of patients with TRK fusion cancer.
Because of the limited number of patients treated with
larotrectinib, information relating to its safety profile in a
broader population and over extended time periods is
lacking. Therefore, there is a need for data in a larger pa-tient population, and for real-world data on larotrectinib
treatment.
This study will describe the safety and effectiveness of
larotrectinib under real-world treatment conditions and
provide information about the management of patients with locally advanced or metastatic TRK fusion cancer in
standard clinical practice.