Peter J M Openshaw
Genetic variability in sporadic amyotrophic lateral sclerosis.
Van Daele S, Moisse M, Farei-Campagna J, Zwamborn R, van der Spek R, van Rheenen W, van Eijk K, Kenna K, Corcia P, Vourc'h P, Couratier P, Hardiman O, McLaughin R, Gotkine M, Drory V, Ticozzi N, Silani V, Ratti A, de Carvalho M, Mora J, Povedano M, Andersen P, Weber M, Başak N, Shaw C, Openshaw P, Morrison K, Landers J, Glass J, van Es M, van den Berg L, Al-Chalabi A, Veldink J, Van Damme P. Genetic variability in sporadic amyotrophic lateral sclerosis. Brain 2023; 146:3760-3769.
01.09.2023Genetic variability in sporadic amyotrophic lateral sclerosis.
01.09.2023Brain 2023; 146:3760-3769
Van Daele Sien Hilde, Moisse Matthieu, Farei-Campagna Jan Marino, Zwamborn Ramona A J, van der Spek Rick, van Rheenen Wouter, van Eijk Kristel R, Kenna Kevin P, Corcia Philippe, Vourc'h Patrick, Couratier Philippe, Hardiman Orla, McLaughin Russell, Gotkine Marc, Drory Vivian E, Ticozzi Nicola, Silani Vincenzo, Ratti Antonia, de Carvalho Mamede, Mora Jesus S, Povedano Monica, Andersen Peter Munch, Weber Markus, Başak Nazli A, Shaw Christopher E, Openshaw Peter J M, Morrison Karen E, Landers John E, Glass Jonathan D, van Es Michael A, van den Berg Leonard H, Al-Chalabi Ammar, Veldink Jan H, Van Damme Philip
Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival.
Adey B, Cooper-Knock J, Al Khleifat A, Fogh I, Van Damme P, Corcia P, Couratier P, Hardiman O, McLaughlin R, Gotkine M, Drory V, Silani V, Ticozzi N, Veldink J, van den Berg L, de Carvalho M, Pinto S, Mora J, Povedano Panades M, Andersen P, Weber M, Başak N, Shaw C, Openshaw P, Morrison K, Landers J, Glass J, Vourc'h P, Dobson R, Breen G, Al-Chalabi A, Jones A, Iacoangeli A. Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival. Front Cell Neurosci 2023; 17:1112405.
02.03.2023Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival.
02.03.2023Front Cell Neurosci 2023; 17:1112405
Adey Brett N, Cooper-Knock Johnathan, Al Khleifat Ahmad, Fogh Isabella, Van Damme Philip, Corcia Philippe, Couratier Philippe, Hardiman Orla, McLaughlin Russell L, Gotkine Marc, Drory Vivian E, Silani Vincenzo, Ticozzi Nicola, Veldink Jan H, van den Berg Leonard H, de Carvalho Mamede, Pinto Susana, Mora Jesus S, Povedano Panades Mónica, Andersen Peter Munch, Weber Markus, Başak Nazli A, Shaw Christopher E, Openshaw Peter J M, Morrison Karen E, Landers John E, Glass Jonathan D, Vourc'h Patrick, Dobson Richard J B, Breen Gerome, Al-Chalabi Ammar, Jones Ashley R, Iacoangeli Alfredo
Whole-genome sequencing reveals host factors underlying critical COVID-19.
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams C, Walker S, Russell C, Malinauskas T, Wu Y, Millar J, Shen X, Elliott K, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple M, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki J, Horowitz J, Baras A, Abecasis G, Ferreira M, Justice A, Mirshahi T, Oetjens M, Rader D, Ritchie M, Verma A, Fowler T, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw P, Elliott P, Walsh T, Tenesa A, Fawkes A, Murphy L, Rowan K, Ponting C, Vitart V, Wilson J, Yang J, Bretherick A, Scott R, Hendry S, Moutsianas L, Law A, Caulfield M, Baillie J, Albrich W. Whole-genome sequencing reveals host factors underlying critical COVID-19. Nature 2022; 607:97-103.
07.03.2022Whole-genome sequencing reveals host factors underlying critical COVID-19.
07.03.2022Nature 2022; 607:97-103
Kousathanas Athanasios, Pairo-Castineira Erola, Rawlik Konrad, Stuckey Alex, Odhams Christopher A, Walker Susan, Russell Clark D, Malinauskas Tomas, Wu Yang, Millar Jonathan, Shen Xia, Elliott Katherine S, Griffiths Fiona, Oosthuyzen Wilna, Morrice Kirstie, Keating Sean, Wang Bo, Rhodes Daniel, Klaric Lucija, Zechner Marie, Parkinson Nick, Siddiq Afshan, Goddard Peter, Donovan Sally, Maslove David, Nichol Alistair D, Semple Malcolm G, Zainy Tala, Maleady-Crowe Fiona, Todd Linda, Salehi Shahla, Knight Julian, Elgar Greg, Chan Georgia, Arumugam Prabhu, Patch Christine, Rendon Augusto, Bentley David, Kingsley Clare, Kosmicki Jack A, Horowitz Julie E, Baras Aris, Abecasis Gonçalo R, Ferreira Manuel A R, Justice Anne E, Mirshahi Tooraj, Oetjens Matthew, Rader Daniel J, Ritchie Marylyn D, Verma Anurag, Fowler Tom A, Shankar-Hari Manu, Summers Charlotte, Hinds Charles, Horby Peter, Ling Lowell, McAuley Danny, Montgomery Hugh, Openshaw Peter J M, Elliott Paul, Walsh Timothy, Tenesa Albert, Fawkes Angie, Murphy Lee, Rowan Kathy, Ponting Chris P, Vitart Veronique, Wilson James F, Yang Jian, Bretherick Andrew D, Scott Richard H, Hendry Sara Clohisey, Moutsianas Loukas, Law Andy, Caulfield Mark J, Baillie J Kenneth, Albrich Werner
Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis.
Zhang S, Cooper-Knock J, Weimer A, Shi M, Moll T, Marshall J, Harvey C, Nezhad H, Franklin J, Souza C, Ning K, Wang C, Li J, Dilliott A, Farhan S, Elhaik E, Pasniceanu I, Livesey M, Eitan C, Hornstein E, Kenna K, PROJECT MINE ALS SEQUENCING CONSORTIUM, Veldink J, Ferraiuolo L, Openshaw P, Snyder M. Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis. Neuron 2022; 110:992-1008.e11.
18.01.2022Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis.
18.01.2022Neuron 2022; 110:992-1008.e11
Zhang Sai, Cooper-Knock Johnathan, Weimer Annika K, Shi Minyi, Moll Tobias, Marshall Jack N G, Harvey Calum, Nezhad Helia Ghahremani, Franklin John, Souza Cleide Dos Santos, Ning Kaida, Wang Cheng, Li Jingjing, Dilliott Allison A, Farhan Sali, Elhaik Eran, Pasniceanu Iris, Livesey Matthew R, Eitan Chen, Hornstein Eran, Kenna Kevin P, PROJECT MINE ALS SEQUENCING CONSORTIUM, Veldink Jan H, Ferraiuolo Laura, Openshaw Peter J M, Snyder Michael P
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
van Rheenen W, van der Spek R, Bakker M, Farei-Campagna J, Hop P, Zwamborn R, de Klein N, Westra H, Bakker O, Deelen P, Shireby G, Hannon E, Moisse M, Baird D, Restuadi R, Dolzhenko E, Dekker A, Gawor K, Westeneng H, Tazelaar G, van Eijk K, Kooyman M, Byrne R, Doherty M, Heverin M, Al Khleifat A, Iacoangeli A, Shatunov A, Ticozzi N, Cooper-Knock J, Smith B, Gromicho M, Chandran S, Pal S, Morrison K, Openshaw P, Hardy J, Orrell R, Sendtner M, Meyer T, Başak N, van der Kooi A, Ratti A, Fogh I, Gellera C, Lauria G, Corti S, Cereda C, Sproviero D, D'Alfonso S, Sorarù G, Siciliano G, Filosto M, Padovani A, Chio A, Calvo A, Moglia C, Brunetti M, Canosa A, Grassano M, Beghi E, Pupillo E, Logroscino G, Nefussy B, Osmanovic A, Nordin A, Lerner Y, Zabari M, Gotkine M, Baloh R, Bell S, Vourc'h P, Corcia P, Couratier P, Millecamps S, Meininger V, Salachas F, Mora J, Assialioui A, Rojas-García R, Dion P, Ross J, Ludolph A, Weishaupt J, Brenner D, Freischmidt A, Bensimon G, Brice A, Dürr A, Payan C, Saker-Delye S, Wood N, Topp S, Rademakers R, Tittmann L, Lieb W, Klein-Franke A, Ripke S, Braun A, Kraft J, Whiteman D, Olsen C, Uitterlinden A, Hofman A, Rietschel M, Cichon S, Nöthen M, Amouyel P, SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium, Traynor B, Singleton A, Mitne Neto M, Cauchi R, Ophoff R, Wiedau-Pazos M, Lomen-Hoerth C, Van Deerlin V, Grosskreutz J, Roediger A, Gaur N, Jörk A, Barthel T, Theele E, Ilse B, Stubendorff B, Witte O, Steinbach R, Hübner C, Graff C, Brylev L, Fominykh V, Demeshonok V, Ataulina A, Rogelj B, Koritnik B, Zidar J, Ravnik-Glavač M, Glavač D, Stević Z, Drory V, Povedano M, Blair I, Kiernan M, Benyamin B, Henderson R, Furlong S, Mathers S, McCombe P, Needham M, Ngo S, Nicholson G, Pamphlett R, Rowe D, Steyn F, Williams K, Mather K, Sachdev P, Henders A, Wallace L, de Carvalho M, Pinto S, Petri S, Weber M, Rouleau G, Silani V, Curtis C, Breen G, Glass J, Brown R, Landers J, Shaw C, Andersen P, Groen E, van Es M, Pasterkamp R, Fan D, Garton F, McRae A, Davey Smith G, Gaunt T, Eberle M, Mill J, McLaughlin R, Hardiman O, Kenna K, Wray N, Tsai E, Runz H, Franke L, Al-Chalabi A, Van Damme P, van den Berg L, Veldink J. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet 2021; 53:1636-1648.
06.12.2021Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
06.12.2021Nat Genet 2021; 53:1636-1648
van Rheenen Wouter, van der Spek Rick A A, Bakker Mark K, Farei-Campagna Jan Marino, Hop Paul J, Zwamborn Ramona A J, de Klein Niek, Westra Harm-Jan, Bakker Olivier B, Deelen Patrick, Shireby Gemma, Hannon Eilis, Moisse Matthieu, Baird Denis, Restuadi Restuadi, Dolzhenko Egor, Dekker Annelot M, Gawor Klara, Westeneng Henk-Jan, Tazelaar Gijs H P, van Eijk Kristel R, Kooyman Maarten, Byrne Ross P, Doherty Mark, Heverin Mark, Al Khleifat Ahmad, Iacoangeli Alfredo, Shatunov Aleksey, Ticozzi Nicola, Cooper-Knock Johnathan, Smith Bradley N, Gromicho Marta, Chandran Siddharthan, Pal Suvankar, Morrison Karen E, Openshaw Peter J M, Hardy John, Orrell Richard W, Sendtner Michael, Meyer Thomas, Başak Nazli A, van der Kooi Anneke J, Ratti Antonia, Fogh Isabella, Gellera Cinzia, Lauria Giuseppe, Corti Stefania, Cereda Cristina, Sproviero Daisy, D'Alfonso Sandra, Sorarù Gianni, Siciliano Gabriele, Filosto Massimiliano, Padovani Alessandro, Chio Adriano, Calvo Andrea, Moglia Cristina, Brunetti Maura, Canosa Antonio, Grassano Maurizio, Beghi Ettore, Pupillo Elisabetta, Logroscino Giancarlo, Nefussy Beatrice, Osmanovic Alma, Nordin Angelica, Lerner Yossef, Zabari Michal, Gotkine Marc, Baloh Robert H, Bell Shaughn, Vourc'h Patrick, Corcia Philippe, Couratier Philippe, Millecamps Stéphanie, Meininger Vincent, Salachas François, Mora Jesus S, Assialioui Abdelilah, Rojas-García Ricardo, Dion Patrick A, Ross Jay P, Ludolph Albert C., Weishaupt Jochen H, Brenner David, Freischmidt Axel, Bensimon Gilbert, Brice Alexis, Dürr Alexandra, Payan Christine A M, Saker-Delye Safaa, Wood Nicholas W, Topp Simon, Rademakers Rosa, Tittmann Lukas, Lieb Wolfgang, Klein-Franke Andreas, Ripke Stephan, Braun Alice, Kraft Julia, Whiteman David C, Olsen Catherine M, Uitterlinden André G, Hofman Albert, Rietschel Marcella, Cichon Sven, Nöthen Markus M, Amouyel Philippe, SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium, Traynor Bryan J, Singleton Andrew B, Mitne Neto Miguel, Cauchi Ruben J, Ophoff Roel A, Wiedau-Pazos Martina, Lomen-Hoerth Catherine, Van Deerlin Vivianna M, Grosskreutz Julian, Roediger Annekathrin, Gaur Nayana, Jörk Alexander, Barthel Tabea, Theele Erik, Ilse Benjamin, Stubendorff Beatrice, Witte Otto W, Steinbach Robert, Hübner Christian A, Graff Caroline, Brylev Lev, Fominykh Vera, Demeshonok Vera, Ataulina Anastasia, Rogelj Boris, Koritnik Blaž, Zidar Janez, Ravnik-Glavač Metka, Glavač Damjan, Stević Zorica, Drory Vivian E, Povedano Monica, Blair Ian P, Kiernan Matthew C, Benyamin Beben, Henderson Robert D, Furlong Sarah, Mathers Susan, McCombe Pamela A, Needham Merrilee, Ngo Shyuan T, Nicholson Garth A, Pamphlett Roger, Rowe Dominic B, Steyn Frederik J, Williams Kelly L, Mather Karen A, Sachdev Perminder S, Henders Anjali K, Wallace Leanne, de Carvalho Mamede, Pinto Susana, Petri Susanne, Weber Markus, Rouleau Guy A, Silani Vincenzo, Curtis Charles J, Breen Gerome, Glass Jonathan D, Brown Robert H, Landers John E, Shaw Christopher E, Andersen Peter Munch, Groen Ewout J N, van Es Michael A, Pasterkamp R Jeroen, Fan Dongsheng, Garton Fleur C, McRae Allan F, Davey Smith George, Gaunt Tom R, Eberle Michael A, Mill Jonathan, McLaughlin Russell L, Hardiman Orla, Kenna Kevin P, Wray Naomi R, Tsai Ellen, Runz Heiko, Franke Lude, Al-Chalabi Ammar, Van Damme Philip, van den Berg Leonard H, Veldink Jan H
Value of systematic genetic screening of patients with amyotrophic lateral sclerosis.
Shepheard S, Parker M, Cooper-Knock J, Verber N, Tuddenham L, Heath P, Beauchamp N, Place E, Sollars E, Turner M, Malaspina A, Fratta P, Hewamadduma C, Jenkins T, McDermott C, Wang D, Kirby J, Openshaw P, Project MINE Consortium, Project MinE. Value of systematic genetic screening of patients with amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2021; 92:510-518.
14.02.2021Value of systematic genetic screening of patients with amyotrophic lateral sclerosis.
14.02.2021J Neurol Neurosurg Psychiatry 2021; 92:510-518
Shepheard Stephanie R, Parker Matthew D, Cooper-Knock Johnathan, Verber Nick S, Tuddenham Lee, Heath Paul R, Beauchamp Nick, Place Elsie, Sollars Elizabeth S A, Turner Martin R, Malaspina Andrea, Fratta Pietro, Hewamadduma Channa, Jenkins Thomas M, McDermott Christopher J, Wang Dennis, Kirby Janine, Openshaw Peter J M, Project MINE Consortium, Project MinE
The Effect of SMN Gene Dosage on ALS Risk and Disease Severity.
Moisse M, Zwamborn R, Van Vugt J, van der Spek R, van Rheenen W, Kenna B, van Eijk K, Kenna K, Corcia P, Couratier P, Vourc'h P, Hardiman O, McLaughin R, Gotkine M, Drory V, Ticozzi N, Silani V, de Carvalho M, Mora J, Povedano M, Andersen P, Weber M, Başak N, Chen X, Eberle M, Al-Chalabi A, Shaw C, Openshaw P, Morrison K, Landers J, Glass J, Robberecht W, van Es M, Van den Berg L, Veldink J, Van Damme P, Project MinE Sequencing Consortium. The Effect of SMN Gene Dosage on ALS Risk and Disease Severity. Ann Neurol 2021; 89:686-697.
15.01.2021The Effect of SMN Gene Dosage on ALS Risk and Disease Severity.
15.01.2021Ann Neurol 2021; 89:686-697
Moisse Matthieu, Zwamborn Ramona A J, Van Vugt Joke J F A, van der Spek Rick, van Rheenen Wouter, Kenna Brendan, van Eijk Kristel R, Kenna Kevin P, Corcia Philippe, Couratier Philippe, Vourc'h Patrick, Hardiman Orla, McLaughin Russell, Gotkine Marc, Drory Vivian E, Ticozzi Nicola, Silani Vincenzo, de Carvalho Mamede, Mora Jesus S, Povedano Monica, Andersen Peter Munch, Weber Markus, Başak Nazli A, Chen Xiao, Eberle Michael A, Al-Chalabi Ammar, Shaw Christopher E, Openshaw Peter J M, Morrison Karen E, Landers John E, Glass Jonathan D, Robberecht Wim, van Es Michael, Van den Berg Leonard, Veldink Jan H, Van Damme Philip, Project MinE Sequencing Consortium
repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization.
Tazelaar G, Boeynaems S, De Decker M, Farei-Campagna J, Kool L, Goedee H, McLaughlin R, Sproviero W, Iacoangeli A, Moisse M, Jacquemyn M, Daelemans D, Dekker A, Van Der Spek R, Westeneng H, Kenna K, Assialioui A, Da Silva N, PROJECT MINE ALS SEQUENCING CONSORTIUM, Povedano M, Mora J, Hardiman O, Salachas F, Millecamps S, Vourc'h P, Corcia P, Couratier P, Morrison K, Openshaw P, Shaw C, Pasterkamp R, Landers J, Van Den Bosch L, Robberecht W, Al-Chalabi A, van den Berg L, Van Damme P, Veldink J, van Es M. repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization. Brain Commun 2020; 2:fcaa064.
19.05.2020repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization.
19.05.2020Brain Commun 2020; 2:fcaa064
Tazelaar Gijs H P, Boeynaems Steven, De Decker Mathias, Farei-Campagna Jan Marino, Kool Lindy, Goedee H Stephan, McLaughlin Russell L, Sproviero William, Iacoangeli Alfredo, Moisse Matthieu, Jacquemyn Maarten, Daelemans Dirk, Dekker Annelot M, Van Der Spek Rick A, Westeneng Henk-Jan, Kenna Kevin P, Assialioui Abdelilah, Da Silva Nica, PROJECT MINE ALS SEQUENCING CONSORTIUM, Povedano Monica, Mora Jesus S, Hardiman Orla, Salachas François, Millecamps Stéphanie, Vourc'h Patrick, Corcia Philippe, Couratier Philippe, Morrison Karen E, Openshaw Peter J M, Shaw Christopher E, Pasterkamp R Jeroen, Landers John E, Van Den Bosch Ludo, Robberecht Wim, Al-Chalabi Ammar, van den Berg Leonard H, Van Damme Philip, Veldink Jan H, van Es Michael A