Martin Röcken
Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors.
Knopf P, Stowbur D, Hoffmann S, Hermann N, Maurer A, Bucher V, Poxleitner M, Tako B, Sonanini D, Krishnamachary B, Sinharay S, Fehrenbacher B, Gonzalez-Menendez I, Reckmann F, Bomze D, Flatz L, Kramer D, Schaller M, Forchhammer S, Bhujwalla Z, Quintanilla-Martinez L, Schulze-Osthoff K, Pagel M, Fransen M, Röcken M, Martins A, Pichler B, Ghoreschi K, Kneilling M. Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors. Mol Cancer 2023; 22:207.
15.12.2023Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors.
15.12.2023Mol Cancer 2023; 22:207
Knopf Philipp, Stowbur Dimitri, Hoffmann Sabrina Hl, Hermann Natalie, Maurer Andreas, Bucher Valentina, Poxleitner Marilena, Tako Bredi, Sonanini Dominik, Krishnamachary Balaji, Sinharay Sanhita, Fehrenbacher Birgit, Gonzalez-Menendez Irene, Reckmann Felix, Bomze David, Flatz Lukas, Kramer Daniela, Schaller Martin, Forchhammer Stephan, Bhujwalla Zaver M, Quintanilla-Martinez Leticia, Schulze-Osthoff Klaus, Pagel Mark D, Fransen Marieke F, Röcken Martin, Martins André F, Pichler Bernd, Ghoreschi Kamran, Kneilling Manfred
Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases.
Chatziioannou E, Roßner J, Aung T, Rimm D, Niessner H, Keim U, Serna-Higuita L, Bonzheim I, Kuhn Cuellar L, Westphal D, Steininger J, Meier F, Pop O, Forchhammer S, Flatz L, Eigentler T, Garbe C, Röcken M, Amaral T, Sinnberg T. Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases. EBioMedicine 2023; 93:104644.
07.06.2023Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases.
07.06.2023EBioMedicine 2023; 93:104644
Chatziioannou Eftychia, Roßner Jana, Aung Thazin New, Rimm David L, Niessner Heike, Keim Ulrike, Serna-Higuita Lina María, Bonzheim Irina, Kuhn Cuellar Luis, Westphal Dana, Steininger Julian, Meier Friedegund, Pop Oltin Tiberiu, Forchhammer Stephan, Flatz Lukas, Eigentler Thomas Kurt, Garbe Claus, Röcken Martin, Amaral Teresa, Sinnberg Tobias
imaging of CD8 T cells in metastatic cancer patients: first clinical experience with simultaneous [Zr]Zr-Df-IAB22M2C PET/MRI.
Schwenck J, Sonanini D, Seyfried D, Ehrlichmann W, Kienzle G, Reischl G, Krezer P, Wilson I, Korn R, Gonzalez-Menendez I, Quintanilla-Martinez L, Seith F, Forschner A, Eigentler T, Zender L, Röcken M, Pichler B, Flatz L, Kneilling M, la Fougere C. imaging of CD8 T cells in metastatic cancer patients: first clinical experience with simultaneous [Zr]Zr-Df-IAB22M2C PET/MRI. Theranostics 2023; 13:2408-2423.
17.04.2023imaging of CD8 T cells in metastatic cancer patients: first clinical experience with simultaneous [Zr]Zr-Df-IAB22M2C PET/MRI.
17.04.2023Theranostics 2023; 13:2408-2423
Schwenck Johannes, Sonanini Dominik, Seyfried Dominik, Ehrlichmann Walter, Kienzle Gabriele, Reischl Gerald, Krezer Pascal, Wilson Ian D, Korn Ron, Gonzalez-Menendez Irene, Quintanilla-Martinez Leticia, Seith Ferdinand, Forschner Andrea, Eigentler Thomas Kurt, Zender Lars, Röcken Martin, Pichler Bernd, Flatz Lukas, Kneilling Manfred, la Fougere Christian
Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.
Sinnberg T, Lichtensteiger C, Ali O, Pop O, Risch L, Brugger S, Velic A, Bomze D, Kohler P, Vernazza P, Albrich W, Kahlert C, Abdou M, Wyss N, Hofmeister K, Niessner H, Zinner C, Gilardi M, Tzankov A, Röcken M, Dulovic A, Shambat S, Ruetalo N, Buehler P, Scheier T, Jochum W, Kern L, Henz S, Schneider T, Kuster G, Lampart M, Siegemund M, Bingisser R, Schindler M, Schneiderhan-Marra N, Kalbacher H, McCoy K, Spengler W, Brutsche M, Macek B, Twerenbold R, Penninger J, Matter M, Flatz L, Jochum A. Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19. Am J Respir Crit Care Med 2023; 207:38-49.
01.01.2023Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.
01.01.2023Am J Respir Crit Care Med 2023; 207:38-49
Sinnberg Tobias, Lichtensteiger Christa, Ali Omar Hasan, Pop Oltin T, Risch Lorenz, Brugger Silvio D, Velic Ana, Bomze David, Kohler Philipp, Vernazza Pietro, Albrich Werner, Kahlert Christian, Abdou Marie-Therese, Wyss Nina, Hofmeister Kathrin, Niessner Heike, Zinner Carl, Gilardi Mara, Tzankov Alexandar, Röcken Martin, Dulovic Alex, Shambat Srikanth Mairpady, Ruetalo Natalia, Buehler Philipp K, Scheier Thomas C, Jochum Wolfram, Kern Lukas, Henz Samuel, Schneider Tino, Kuster Gabriela M, Lampart Maurin, Siegemund Martin, Bingisser Roland, Schindler Michael, Schneiderhan-Marra Nicole, Kalbacher Hubert, McCoy Kathy D, Spengler Werner, Brutsche Martin H, Macek Boris, Twerenbold Raphael, Penninger Josef M, Matter Matthias S, Flatz Lukas, Jochum Ann-Kristin
Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study
Wagner N, Schraag A, Klumpp B, Hoetzenecker W, Berking C, Richtig E, Ziemer M, Mangana J, Terheyden P, Loquai C, Nguyen V, Gebhardt C, Meier F, Diem S, Cozzio A, Flatz L, Röcken M, Garbe C, Gassenmaier M, Weide B, Leiter U, Lenders M, Kühl K, Reinhardt L, André F, Dudda M, Ring N, Ebel C, Stäger R, Zellweger C, Lang R, Paar M, Gussek P, Richtig G, Stürmer S, Kimeswenger S, Oellinger A, Forschner A, Eigentler T. Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study. J Immunother Cancer 2021; 9
01.01.2021Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study
01.01.2021J Immunother Cancer 2021; 9
Wagner Nikolaus, Schraag Amadeus, Klumpp Bernhard, Hoetzenecker Wolfram, Berking Carola, Richtig Erika, Ziemer Mirjana, Mangana Johanna, Terheyden Patrick, Loquai Carmen, Nguyen Van Anh, Gebhardt Christoffer, Meier Friedegund, Diem Stefan, Cozzio Antonio, Flatz Lukas, Röcken Martin, Garbe Claus, Gassenmaier Maximilian, Weide Benjamin, Leiter Ulrike, Lenders Max M, Kühl Kathrin, Reinhardt Lydia, André Fiona, Dudda Milena, Ring Natalie, Ebel Chiara, Stäger Ramon, Zellweger Caroline, Lang Roland, Paar Michael, Gussek Philipp, Richtig Georg, Stürmer Suzan H, Kimeswenger Susanne, Oellinger Angela, Forschner Andrea, Eigentler Thomas K
Prognostic role of gamma-glutamyl transferase in metastatic melanoma patients treated with immune checkpoint inhibitors
Winter J, Eigentler T, Garbe C, Röcken M, Cozzio A, Flatz L, Purde M, Weide B, Leiter U, Forschner A, Gassenmaier M, Lenders M, Wagner N. Prognostic role of gamma-glutamyl transferase in metastatic melanoma patients treated with immune checkpoint inhibitors. Cancer Immunol Immunother 2020; 70:1089-1099.
28.10.2020Prognostic role of gamma-glutamyl transferase in metastatic melanoma patients treated with immune checkpoint inhibitors
28.10.2020Cancer Immunol Immunother 2020; 70:1089-1099
Winter Johanna, Eigentler Thomas K, Garbe Claus, Röcken Martin, Cozzio Antonio, Flatz Lukas, Purde Mette-Triin, Weide Benjamin, Leiter Ulrike, Forschner Andrea, Gassenmaier Maximilian, Lenders Max M, Wagner Nikolaus
Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors
Gassenmaier M, Garbe C, Schaller M, Wagner N, Bösmüller H, Niessner H, Sinnberg T, Kosnopfel C, Ikenberg K, Eigentler T, Fehrenbacher B, Rentschler M, Röcken M. Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors. Am J Pathol 2020; 190:2155-2164.
15.07.2020Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors
15.07.2020Am J Pathol 2020; 190:2155-2164
Gassenmaier Maximilian, Garbe Claus, Schaller Martin, Wagner Nikolaus, Bösmüller Hans, Niessner Heike, Sinnberg Tobias, Kosnopfel Corinna, Ikenberg Kristian, Eigentler Thomas K, Fehrenbacher Birgit, Rentschler Maximilian, Röcken Martin
Uniparental Disomy of Chromosome 2 Unmasks New ITGA6 Recessive Mutation and Results in a Lethal Junctional Epidermolysis Bullosa in a Newborn
Higgins R, Fischer T, Schwieger-Briel A, French L, Hoetzenecker W, Hornung R, Malzacher A, Cozzio A, Navarini A, Has C, Chang Y, Desislava I, Jensen A, Wachstein J, Bruckner-Tuderman L, Spiegel R, Traber H, Achermann J, Schaller M, Fehrenbacher B, Röcken M, Guenova E. Uniparental Disomy of Chromosome 2 Unmasks New ITGA6 Recessive Mutation and Results in a Lethal Junctional Epidermolysis Bullosa in a Newborn. Acta Derm Venereol 2020; 100:adv00041.
30.01.2020Uniparental Disomy of Chromosome 2 Unmasks New ITGA6 Recessive Mutation and Results in a Lethal Junctional Epidermolysis Bullosa in a Newborn
30.01.2020Acta Derm Venereol 2020; 100:adv00041
Higgins Rebecca, Fischer Tina, Schwieger-Briel Agnes E, French Lars E, Hoetzenecker Wolfram, Hornung René, Malzacher Andreas, Cozzio Antonio, Navarini Alexander, Has Cristina, Chang Yun-Tsan, Desislava Ignatova, Jensen Annika N, Wachstein Julian, Bruckner-Tuderman Leena, Spiegel Roland, Traber Hubert, Achermann Josef, Schaller Martin, Fehrenbacher Birgit, Röcken Martin, Guenova Emmanuella
Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid
Mehra T, Guenova E, Dechent F, Würth F, Zierhut M, Röcken M, Schaller M, Deuter C. Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid. J Dtsch Dermatol Ges 2015; 13:1268-74.
01.12.2015Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid
01.12.2015J Dtsch Dermatol Ges 2015; 13:1268-74
Mehra Tarun, Guenova Emmanuella, Dechent Frieder, Würth Florian, Zierhut Manfred, Röcken Martin, Schaller Martin, Deuter Christoph
IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells
Guenova E, Kaesler S, Thomas P, Mailhammer R, Ghoreschi K, Schäkel K, Amarov B, Eichner M, Schaller M, Clark R, Röcken M, Köberle M, Volz T, Levesque M, Skabytska Y, Hoetzenecker W, Weindl G, Sauer K, Tham M, Kim K, Park J, Seo J, Desislava I, Cozzio A, Biedermann T. IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells. Proc Natl Acad Sci USA 2015; 112:2163-8.
02.02.2015IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells
02.02.2015Proc Natl Acad Sci USA 2015; 112:2163-8
Guenova Emmanuella, Kaesler Susanne, Thomas Peter, Mailhammer Reinhard, Ghoreschi Kamran, Schäkel Knut, Amarov Boyko, Eichner Martin, Schaller Martin, Clark Rachael A, Röcken Martin, Köberle Martin, Volz Thomas, Levesque Mitchell P, Skabytska Yuliya, Hoetzenecker Wolfram, Weindl Günther, Sauer Karin, Tham Manuela, Kim Kyu-Won, Park Ji-Hyeon, Seo Ji Hae, Desislava Ignatova, Cozzio Antonio, Biedermann Tilo
Cutaneous innate immune sensing of Toll-like receptor 2-6 ligands suppresses T cell immunity by inducing myeloid-derived suppressor cells
Skabytska Y, Götz F, Röcken M, Schaller M, Rammensee H, Volz T, Kempf W, Demircioglu D, Guenova E, Chen K, Kaesler S, Köberle M, Günther C, Wölbing F, Biedermann T. Cutaneous innate immune sensing of Toll-like receptor 2-6 ligands suppresses T cell immunity by inducing myeloid-derived suppressor cells. Immunity 2014; 41:762-75.
13.11.2014Cutaneous innate immune sensing of Toll-like receptor 2-6 ligands suppresses T cell immunity by inducing myeloid-derived suppressor cells
13.11.2014Immunity 2014; 41:762-75
Skabytska Yuliya, Götz Friedrich, Röcken Martin, Schaller Martin, Rammensee Hans-Georg, Volz Thomas, Kempf Wolfgang E, Demircioglu Doruk, Guenova Emmanuella, Chen Ko-Ming, Kaesler Susanne, Köberle Martin, Günther Claudia, Wölbing Florian, Biedermann Tilo
Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma
Mehra T, Naumann A, Clasen S, Dummer R, Claussen C, Röcken M, Moos R, Guenova E, Mann S, Grözinger G, Garbe C. Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma. PloS one 2014; 9:e112535.
10.11.2014Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma
10.11.2014PloS one 2014; 9:e112535
Mehra Tarun, Naumann Aline, Clasen Stephan, Dummer Reinhard, Claussen Claus Detlef, Röcken Martin, Moos Rudolf, Guenova Emmanuella, Mann Steven, Grözinger Gerd, Garbe Claus
Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4-mediated suppression of IL-10
Kaesler S, Röcken M, Wölbing F, Guenova E, Chen K, Hein U, Köberle M, Skabytska Y, Volz T, Biedermann T. Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4-mediated suppression of IL-10. J Allergy Clin Immunol 2014; 134:92-9.
01.04.2014Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4-mediated suppression of IL-10
01.04.2014J Allergy Clin Immunol 2014; 134:92-9
Kaesler Susanne, Röcken Martin, Wölbing Florian, Guenova Emmanuella, Chen Ko-Ming, Hein Ulrike, Köberle Martin, Skabytska Yuliya, Volz Thomas, Biedermann Tilo
Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells
Volz T, Skabytska Y, Guenova E, Chen K, Frick J, Kirschning C, Kaesler S, Röcken M, Biedermann T. Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells. J Invest Dermatol 2013; 134:96-104.
28.06.2013Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells
28.06.2013J Invest Dermatol 2013; 134:96-104
Volz Thomas, Skabytska Yuliya, Guenova Emmanuella, Chen Ko-Ming, Frick Julia-Stefanie, Kirschning Carsten J, Kaesler Susanne, Röcken Martin, Biedermann Tilo
ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression
Hoetzenecker W, Biedermann T, Ghoreschi K, Hai T, Krenn C, Hoffmann P, Kim K, Kim K, Park J, Kneilling M, Fuchs K, Valtcheva N, Teske A, Brück J, Woelbing F, Hoetzenecker K, Guenova E, Echtenacher B, Röcken M. ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nat Med 2011; 18:128-34.
18.12.2011ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression
18.12.2011Nat Med 2011; 18:128-34
Hoetzenecker Wolfram, Biedermann Tilo, Ghoreschi Kamran, Hai Tsonwin, Krenn Claus, Hoffmann Petra, Kim Kyu-Won, Kim Kyu-Han, Park Ji-Hyeon, Kneilling Manfred, Fuchs Kerstin, Valtcheva Nadejda, Teske Anna, Brück Jürgen, Woelbing Florian, Hoetzenecker Konrad, Guenova Emmanuella, Echtenacher Bernd, Röcken Martin
Natural Staphylococcus aureus-derived peptidoglycan fragments activate NOD2 and act as potent costimulators of the innate immune system exclusively in the presence of TLR signals
Volz T, Nega M, Buschmann J, Kaesler S, Guenova E, Peschel A, Röcken M, Götz F, Biedermann T. Natural Staphylococcus aureus-derived peptidoglycan fragments activate NOD2 and act as potent costimulators of the innate immune system exclusively in the presence of TLR signals. FASEB J 2010; 24:4089-102.
03.06.2010Natural Staphylococcus aureus-derived peptidoglycan fragments activate NOD2 and act as potent costimulators of the innate immune system exclusively in the presence of TLR signals
03.06.2010FASEB J 2010; 24:4089-102
Volz Thomas, Nega Mulugeta, Buschmann Julia, Kaesler Susanne, Guenova Emmanuella, Peschel Andreas, Röcken Martin, Götz Friedrich, Biedermann Tilo
Successful treatment of recalcitrant lymphomatoid papulosis in a child with PUVA-bath photochemotherapy
Hoetzenecker W, Guenova E, Hoetzenecker K, Yazdi A, Röcken M, Berneburg M. Successful treatment of recalcitrant lymphomatoid papulosis in a child with PUVA-bath photochemotherapy. Eur J Dermatol 2009; 19:646-7.
01.10.2009Successful treatment of recalcitrant lymphomatoid papulosis in a child with PUVA-bath photochemotherapy
01.10.2009Eur J Dermatol 2009; 19:646-7
Hoetzenecker Wolfram, Guenova Emmanuella, Hoetzenecker Konrad, Yazdi Amir, Röcken Martin, Berneburg Mark
IL-4-mediated fine tuning of IL-12p70 production by human DC
Guenova E, Röcken M, Brossart P, Schwärzler C, Chen K, Wölbing F, Müller M, Kaesler S, Sauer K, Volz T, Biedermann T. IL-4-mediated fine tuning of IL-12p70 production by human DC. Eur J Immunol 2008; 38:3138-49.
01.11.2008IL-4-mediated fine tuning of IL-12p70 production by human DC
01.11.2008Eur J Immunol 2008; 38:3138-49
Guenova Emmanuella, Röcken Martin, Brossart Peter, Schwärzler Christoph, Chen KoMing, Wölbing Florian, Müller Martin R, Kaesler Susanne, Sauer Karin, Volz Thomas, Biedermann Tilo
Palmar-plantar erythrodysesthesia secondary to sunitinib treatment resulting in necrotic foot syndrome aggravated by background diabetic vascular disease
Guenova E, Weber H, Voykov B, Metzler G, Mitev V, Berneburg M, Hoetzenecker W, Röcken M. Palmar-plantar erythrodysesthesia secondary to sunitinib treatment resulting in necrotic foot syndrome aggravated by background diabetic vascular disease. Arch Dermatol 2008; 144:1081-2.
01.08.2008Palmar-plantar erythrodysesthesia secondary to sunitinib treatment resulting in necrotic foot syndrome aggravated by background diabetic vascular disease
01.08.2008Arch Dermatol 2008; 144:1081-2
Guenova Emmanuella, Weber Hans Oliver, Voykov Bogmil, Metzler Gisela, Mitev Vanyo, Berneburg Mark, Hoetzenecker Wolfram, Röcken Martin
Classic Mediterranean Kaposi's sarcoma regression with sirolimus treatment
Guenova E, Metzler G, Hoetzenecker W, Berneburg M, Röcken M. Classic Mediterranean Kaposi's sarcoma regression with sirolimus treatment. Arch Dermatol 2008; 144:692-3.
01.05.2008Classic Mediterranean Kaposi's sarcoma regression with sirolimus treatment
01.05.2008Arch Dermatol 2008; 144:692-3
Guenova Emmanuella, Metzler Gisela, Hoetzenecker Wolfram, Berneburg Mark, Röcken Martin