Cell-Free Oxyhemoglobin in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage: Biomarker and Potential Therapeutic Target.

Publication

Cell-Free Oxyhemoglobin in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage: Biomarker and Potential Therapeutic Target.

Journal Paper/Review - Aug 27, 2018

Hugelshofer Michael, Sikorski Christopher M, Seule Martin, Deuel Jeremy, Muroi Carl I, Seboek Martina, Akeret Kevin, Buzzi Raphael, Regli Luca, Schaer Dominik J, Keller Emanuela

Citation

Hugelshofer M, Sikorski C, Seule M, Deuel J, Muroi C, Seboek M, Akeret K, Buzzi R, Regli L, Schaer D, Keller E. Cell-Free Oxyhemoglobin in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage: Biomarker and Potential Therapeutic Target. World Neurosurg 2018; 120:e660-e666.

Type

Journal Paper/Review (English)

Journal

World Neurosurg 2018; 120

Publication Date

Aug 27, 2018

Issn Electronic

1878-8769

Pages

e660-e666

Brief description/objective

Aneurysmal subarachnoid hemorrhage (aSAH) is often complicated by the occurrence of delayed ischemic neurologic deficits (DIND), which impairs the clinical outcome of patients. The release of oxyhemoglobin (oxyHb) from lysing erythrocytes into cerebrospinal fluid (CSF) may critically contribute to the development of DIND.