Publication

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Journal Paper/Review - Jun 26, 2009

Units
PubMed
Doi

Citation
Morris A, Stringham H, Swift A, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters G, Weedon M, Witteman J, Zhang C, Zhang W, Caulfield M, Collins F, Davey Smith G, Yuan X, Song K, Munroe P, Narisu N, Nordström A, Nordström P, Oostra B, Palmer C, Payne F, Peden J, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu M, Scott L, Scuteri A, Silander K, Day I, Franks P, Hugh Watkins, Waterworth D, Boehnke M, Deloukas P, Groop L, Hunter D, Thorsteinsdottir U, Schlessinger D, Wichmann H, Frayling T, Abecasis G, Hirschhorn J, Loos R, Stefansson K, Mohlke K, Barroso I, Wareham N, van Duijn C, Hattersley A, Hu F, Jarvelin M, Kong A, Kooner J, Laakso M, Lakatta E, Mooser V, Morris A, Peltonen L, Samani N, Spector T, Strachan D, Tanaka T, Tuomilehto J, Uitterlinden A, McCarthy M, Lindgren C, Lyon H, Rivadeneira F, Sanna S, Timpson N, Zillikens M, Zhao J, Almgren P, Bandinelli S, Bennett A, Bergman R, Bonnycastle L, Bumpstead S, Chanock S, Cherkas L, Chines P, Coin L, Luan J, Drong A, Heid I, Randall J, Lamina C, Steinthorsdottir V, Qi L, Speliotes E, Thorleifsson G, Willer C, Herrera B, Jackson A, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko Y, Chambers J, Cooper C, Crawford G, Hofman A, Holle R, Holloway J, Illig T, Isomaa B, Jacobs L, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop G, Lawlor D, Mangino M, McArdle W, Meitinger T, Havulinna A, Hamsten A, Doering A, Dominiczak A, Doney A, Ebrahim S, Elliott P, Erdos M, Estrada K, Ferrucci L, Fischer G, Forouhi N, Gieger C, Grallert H, Groves C, Grundy S, Guiducci C, Hadley D, Morken M. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009; 5:e1000508.
Type
Journal Paper/Review (English)
Journal
PLoS Genet 2009; 5
Publication Date
Jun 26, 2009
Issn Electronic
1553-7404
Pages
e1000508
Brief description/objective

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.