Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Publication

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Journal Paper/Review - Jun 26, 2009

Morris Andrew P, Stringham Heather M, Swift Amy J, Tuomi Tiinamaija, Uda Manuela, Vollenweider Peter, Waeber Gerard, Wallace Chris, Walters G Bragi, Weedon Michael N, Witteman Jacqueline C M, Zhang Cuilin, Zhang Weihua, Caulfield Mark J, Collins Francis S, Davey Smith George, Yuan Xin, Song Kijoung, Munroe Patricia, Narisu Narisu, Nordström Anna, Nordström Peter, Oostra Ben A, Palmer Colin N A, Payne Felicity, Peden John F, Prokopenko Inga, Renström Frida, Ruokonen Aimo, Salomaa Veikko, Sandhu Manjinder S, Scott Laura J, Scuteri Angelo, Silander Kaisa, Day Ian N M, Franks Paul W, Hugh Watkins, Waterworth Dawn M, Boehnke Michael, Deloukas Panos, Groop Leif, Hunter David J, Thorsteinsdottir Unnur, Schlessinger David, Wichmann H-Erich, Frayling Timothy M, Abecasis Gonçalo R, Hirschhorn Joel N, Loos Ruth J F, Stefansson Kari, Mohlke Karen L, Barroso Inês, Wareham Nicholas J, van Duijn Cornelia M, Hattersley Andrew T, Hu Frank B, Jarvelin Marjo-Riitta, Kong Augustine, Kooner Jaspal S, Laakso Markku, Lakatta Edward, Mooser Vincent, Morris Andrew D, Peltonen Leena, Samani Nilesh J, Spector Timothy D, Strachan David P, Tanaka Toshiko, Tuomilehto Jaakko, Uitterlinden André G, McCarthy Mark I, Lindgren Cecilia M, Lyon Helen N, Rivadeneira Fernando, Sanna Serena, Timpson Nicholas J, Zillikens M Carola, Zhao Jing Hua, Almgren Peter, Bandinelli Stefania, Bennett Amanda J, Bergman Richard N, Bonnycastle Lori L, Bumpstead Suzannah J, Chanock Stephen J, Cherkas Lynn, Chines Peter, Coin Lachlan, Luan Jian'an, Drong Alexander, Heid Iris M, Randall Joshua C, Lamina Claudia, Steinthorsdottir Valgerdur, Qi Lu, Speliotes Elizabeth K, Thorleifsson Gudmar, Willer Cristen J, Herrera Blanca M, Jackson Anne U, Lim Noha, Scheet Paul, Soranzo Nicole, Amin Najaf, Aulchenko Yurii S, Chambers John C, Cooper Cyrus, Crawford Gabriel, Hofman Albert, Holle Rolf, Holloway John W, Illig Thomas, Isomaa Bo, Jacobs Leonie C, Jameson Karen, Jousilahti Pekka, Karpe Fredrik, Kuusisto Johanna, Laitinen Jaana, Lathrop G Mark, Lawlor Debbie A, Mangino Massimo, McArdle Wendy L, Meitinger Thomas, Havulinna Aki S, Hamsten Anders, Doering Angela, Dominiczak Anna, Doney Alex S F, Ebrahim Shah, Elliott Paul, Erdos Michael R, Estrada Karol, Ferrucci Luigi, Fischer Guido, Forouhi Nita G, Gieger Christian, Grallert Harald, Groves Christopher J, Grundy Scott, Guiducci Candace, Hadley David, Morken Mario A

Citation

Morris A, Stringham H, Swift A, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters G, Weedon M, Witteman J, Zhang C, Zhang W, Caulfield M, Collins F, Davey Smith G, Yuan X, Song K, Munroe P, Narisu N, Nordström A, Nordström P, Oostra B, Palmer C, Payne F, Peden J, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu M, Scott L, Scuteri A, Silander K, Day I, Franks P, Hugh Watkins, Waterworth D, Boehnke M, Deloukas P, Groop L, Hunter D, Thorsteinsdottir U, Schlessinger D, Wichmann H, Frayling T, Abecasis G, Hirschhorn J, Loos R, Stefansson K, Mohlke K, Barroso I, Wareham N, van Duijn C, Hattersley A, Hu F, Jarvelin M, Kong A, Kooner J, Laakso M, Lakatta E, Mooser V, Morris A, Peltonen L, Samani N, Spector T, Strachan D, Tanaka T, Tuomilehto J, Uitterlinden A, McCarthy M, Lindgren C, Lyon H, Rivadeneira F, Sanna S, Timpson N, Zillikens M, Zhao J, Almgren P, Bandinelli S, Bennett A, Bergman R, Bonnycastle L, Bumpstead S, Chanock S, Cherkas L, Chines P, Coin L, Luan J, Drong A, Heid I, Randall J, Lamina C, Steinthorsdottir V, Qi L, Speliotes E, Thorleifsson G, Willer C, Herrera B, Jackson A, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko Y, Chambers J, Cooper C, Crawford G, Hofman A, Holle R, Holloway J, Illig T, Isomaa B, Jacobs L, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop G, Lawlor D, Mangino M, McArdle W, Meitinger T, Havulinna A, Hamsten A, Doering A, Dominiczak A, Doney A, Ebrahim S, Elliott P, Erdos M, Estrada K, Ferrucci L, Fischer G, Forouhi N, Gieger C, Grallert H, Groves C, Grundy S, Guiducci C, Hadley D, Morken M. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009; 5:e1000508.

Type

Journal Paper/Review (English)

Journal

PLoS Genet 2009; 5

Publication Date

Jun 26, 2009

Issn Electronic

1553-7404

Pages

e1000508

Brief description/objective

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.