Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations

Publication

Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations

Journal Paper/Review - Mar 15, 2018

Bueno-de-Mesquita H Bas, Dorronsoro Miren, Sánchez María-José, Obón-Santacana Mireia, Lasheras Cristina, Olsen Karina Standahl, Brustad Magritt, Peeters Petra, Matullo Giuseppe, Panico Salvatore, Tumino Rosario, Agnoli Claudia, Chirlaque Maria-Dolores, Barricarte Aurelio, Riboli Elio, Norat Teresa, Aune Dagfinn, Freisling Heinz, Bradbury Kathryn E, Khaw Kay-Tee, Wareham Nick, Ye Weimin, Renström Frida, Almquist Martin, Manjer Jonas, Palli Domenico, Kritikou Maria, Murphy Neil, Weiderpass Elisabete, van den Ouweland Jody M W, van Kranen Henk J, Halfweeg Anouk, Kampman Ellen, Duell Eric J, Fedirko Veronika, Siersema Peter D, Hveem Kristian, Jenab Mazda, Langhammer Arnulf, Ness-Jensen Eivind, Kotanidou Anastasia, Trichopoulou Antonia, Boeing Heiner, Kühn Tilman, Katzke Verena A, Boutron-Ruault Marie-Christine, Kvaskoff Marina, Cadeau Claire, Overvad Kim, Tjønneland Anne, Olsen Anja, van Duijnhoven Fränzel J B

Citation

Bueno-de-Mesquita H, Dorronsoro M, Sánchez M, Obón-Santacana M, Lasheras C, Olsen K, Brustad M, Peeters P, Matullo G, Panico S, Tumino R, Agnoli C, Chirlaque M, Barricarte A, Riboli E, Norat T, Aune D, Freisling H, Bradbury K, Khaw K, Wareham N, Ye W, Renström F, Almquist M, Manjer J, Palli D, Kritikou M, Murphy N, Weiderpass E, van den Ouweland J, van Kranen H, Halfweeg A, Kampman E, Duell E, Fedirko V, Siersema P, Hveem K, Jenab M, Langhammer A, Ness-Jensen E, Kotanidou A, Trichopoulou A, Boeing H, Kühn T, Katzke V, Boutron-Ruault M, Kvaskoff M, Cadeau C, Overvad K, Tjønneland A, Olsen A, van Duijnhoven F. Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations. Int J Cancer 2018; 142:1189-1201.

Type

Journal Paper/Review (English)

Journal

Int J Cancer 2018; 142

Publication Date

Mar 15, 2018

Issn Electronic

1097-0215

Pages

1189-1201

Brief description/objective

Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.