Daptomycin for highly resistant Enterococcus faecium infection

Publication

Daptomycin for highly resistant Enterococcus faecium infection

Journal Paper/Review - Jun 26, 2012

Rosin Christiane, Bernsmeier Christine, Entenza José M, Moreillon Philippe, Frei Reno, Maja Weisser, Fluckiger Ursula

Citation

Rosin C, Bernsmeier C, Entenza J, Moreillon P, Frei R, Maja W, Fluckiger U. Daptomycin for highly resistant Enterococcus faecium infection. Swiss Med Wkly 2012; 142:w13603.

Type

Journal Paper/Review (English)

Journal

Swiss Med Wkly 2012; 142

Publication Date

Jun 26, 2012

Issn Electronic

1424-3997

Pages

w13603

Brief description/objective

We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC >8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC >500 mg/l). All patients were treated with multiple broad-spectrum antibiotics prior to isolation of E. faecium and had severe underlying diseases. Our experience suggests that salvage therapy with daptomycin might be a safe and efficacious treatment for E. faecium infections.