Publication
Daptomycin for highly resistant Enterococcus faecium infection
Journal Paper/Review - Jun 26, 2012
Rosin Christiane, Bernsmeier Christine, Entenza José M, Moreillon Philippe, Frei Reno, Maja Weisser, Fluckiger Ursula
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Pages
Brief description/objective
We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC >8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC >500 mg/l). All patients were treated with multiple broad-spectrum antibiotics prior to isolation of E. faecium and had severe underlying diseases. Our experience suggests that salvage therapy with daptomycin might be a safe and efficacious treatment for E. faecium infections.