Publication

Daptomycin for highly resistant Enterococcus faecium infection

Journal Paper/Review - Jun 26, 2012

Units
PubMed
Doi

Citation
Rosin C, Bernsmeier C, Entenza J, Moreillon P, Frei R, Maja W, Fluckiger U. Daptomycin for highly resistant Enterococcus faecium infection. Swiss Med Wkly 2012; 142:w13603.
Type
Journal Paper/Review (English)
Journal
Swiss Med Wkly 2012; 142
Publication Date
Jun 26, 2012
Issn Electronic
1424-3997
Pages
w13603
Brief description/objective

We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC >8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC >500 mg/l). All patients were treated with multiple broad-spectrum antibiotics prior to isolation of E. faecium and had severe underlying diseases. Our experience suggests that salvage therapy with daptomycin might be a safe and efficacious treatment for E. faecium infections.