Reactive macrophage activation syndrome: a simple screening strategy and its potential in early treatment initiation

Publication

Reactive macrophage activation syndrome: a simple screening strategy and its potential in early treatment initiation

Journal Paper/Review - May 4, 2002

Emmenegger U, Spaeth P J, Cerny A, Cottagnoud P, Semela David, Bihl F, Fux Ch, Frey U, Reimers A, Neftel Klaus A

Citation

Emmenegger U, Spaeth P, Cerny A, Cottagnoud P, Semela D, Bihl F, Fux C, Frey U, Reimers A, Neftel K. Reactive macrophage activation syndrome: a simple screening strategy and its potential in early treatment initiation. Swiss Med Wkly 2002; 132:230-6.

Type

Journal Paper/Review (English)

Journal

Swiss Med Wkly 2002; 132

Publication Date

May 4, 2002

Issn Print

1424-7860

Pages

230-6

Brief description/objective

starting treatment of reactive macrophage activation syndromes as early as possible (rMAS, haemophagocytic lymphohistiocytosis), e.g., with intravenous immunoglobulins (IVIG), seems to be essential for optimal outcome. However, there is no diagnostic gold standard which reliably indicates need for early treatment. We used a simple screening strategy consisting of serum ferritin measurements and/or morphological assessment of haemophagocytosis and compared the studied patient population with published series.