Publication

Familial cutaneous mycosis fungoides: successful treatment with a combination of gemcitabine and alemtuzumab

Journal Paper/Review - Jan 1, 2004

Units
PubMed
Doi

Citation
Weder P, Anliker M, Itin P, Bargetzi M. Familial cutaneous mycosis fungoides: successful treatment with a combination of gemcitabine and alemtuzumab. Dermatology (Basel, Switzerland) 2004; 208:281-3.
Type
Journal Paper/Review (English)
Journal
Dermatology (Basel, Switzerland) 2004; 208
Publication Date
Jan 1, 2004
Issn Print
1018-8665
Pages
281-3
Brief description/objective

We report a familial cutaneous T-cell lymphoma in father and son. After different treatment modalities without lasting responses, the son was treated with gemcitabine as single agent and due to insufficient effect with alemtuzumab monotherapy. Only after the two drugs had been combined did we observe a remarkable response of the skin lesions and disappearance of enlarged lymph nodes. The combined treatment with gemcitabine and alemtuzumab was well tolerated, and no increased toxicity was noted. The combination of these two active agents may provide an additional option in the treatment of cutaneous T-cell lymphoma.