Familial cutaneous mycosis fungoides: successful treatment with a combination of gemcitabine and alemtuzumab

Publication

Familial cutaneous mycosis fungoides: successful treatment with a combination of gemcitabine and alemtuzumab

Journal Paper/Review - Jan 1, 2004

Weder Patrik, Anliker M, Itin P, Bargetzi M

Citation

Weder P, Anliker M, Itin P, Bargetzi M. Familial cutaneous mycosis fungoides: successful treatment with a combination of gemcitabine and alemtuzumab. Dermatology (Basel, Switzerland) 2004; 208:281-3.

Type

Journal Paper/Review (English)

Journal

Dermatology (Basel, Switzerland) 2004; 208

Publication Date

Jan 1, 2004

Issn Print

1018-8665

Pages

281-3

Brief description/objective

We report a familial cutaneous T-cell lymphoma in father and son. After different treatment modalities without lasting responses, the son was treated with gemcitabine as single agent and due to insufficient effect with alemtuzumab monotherapy. Only after the two drugs had been combined did we observe a remarkable response of the skin lesions and disappearance of enlarged lymph nodes. The combined treatment with gemcitabine and alemtuzumab was well tolerated, and no increased toxicity was noted. The combination of these two active agents may provide an additional option in the treatment of cutaneous T-cell lymphoma.