Treatment of hepatitis C in HCV mono-infected and in HIV-HCV co-infected patients: an open-labelled comparison study

Publication

Treatment of hepatitis C in HCV mono-infected and in HIV-HCV co-infected patients: an open-labelled comparison study

Journal Paper/Review - Jul 19, 2010

Gonvers Jean-Jacques, Troilliet Nicolas, Negro Francesco, Monnat Martine, Malinverni Raffaelle, Dutoit Valérie, Dufour François, Chuard Christian, Chave Jean-Philippe, Cerny Andreas, Borovicka Jan, Bernasconi Enos, Genné Daniel, Mullhaupt Beat, Cavassini Matthias, Heim Markus H, Oneta Carl

Citation

Gonvers J, Troilliet N, Negro F, Monnat M, Malinverni R, Dutoit V, Dufour F, Chuard C, Chave J, Cerny A, Borovicka J, Bernasconi E, Genné D, Mullhaupt B, Cavassini M, Heim M, Oneta C. Treatment of hepatitis C in HCV mono-infected and in HIV-HCV co-infected patients: an open-labelled comparison study. Swiss Med Wkly 2010; 140:w13055.

Type

Journal Paper/Review (English)

Journal

Swiss Med Wkly 2010; 140

Publication Date

Jul 19, 2010

Issn Electronic

1424-3997

Pages

w13055

Brief description/objective

Treatment of chronic HCV infection has become a priority in HIV+ patients, given the faster progression to end-stage liver disease. The primary endpoint of this study was to evaluate and compare antiviral efficacy of Peginterferon alpha 2a plus ribavirin in HIV-HCV co-infected and HCV mono-infected patients, and to examine whether 6 months of therapy would have the same efficacy in HIV patients with favourable genotypes 2 and 3 as in mono-infected patients, to minimise HCV-therapy-related toxicities. Secondary endpoints were to evaluate predictors of sustained virological response (SVR) and frequency of side-effects.