Publication

Treatment of hepatitis C in HCV mono-infected and in HIV-HCV co-infected patients: an open-labelled comparison study

Journal Paper/Review - Jul 19, 2010

Units
PubMed
Doi

Citation
Gonvers J, Troilliet N, Negro F, Monnat M, Malinverni R, Dutoit V, Dufour F, Chuard C, Chave J, Cerny A, Borovicka J, Bernasconi E, Genné D, Mullhaupt B, Cavassini M, Heim M, Oneta C. Treatment of hepatitis C in HCV mono-infected and in HIV-HCV co-infected patients: an open-labelled comparison study. Swiss Med Wkly 2010; 140:w13055.
Type
Journal Paper/Review (English)
Journal
Swiss Med Wkly 2010; 140
Publication Date
Jul 19, 2010
Issn Electronic
1424-3997
Pages
w13055
Brief description/objective

Treatment of chronic HCV infection has become a priority in HIV+ patients, given the faster progression to end-stage liver disease. The primary endpoint of this study was to evaluate and compare antiviral efficacy of Peginterferon alpha 2a plus ribavirin in HIV-HCV co-infected and HCV mono-infected patients, and to examine whether 6 months of therapy would have the same efficacy in HIV patients with favourable genotypes 2 and 3 as in mono-infected patients, to minimise HCV-therapy-related toxicities. Secondary endpoints were to evaluate predictors of sustained virological response (SVR) and frequency of side-effects.