Receptor-mediated targeting of cathepsins in professional antigen presenting cells

Publication

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

Journal Paper/Review - Jan 1, 2009

Hillaert Ulrik, Driessen Christoph, van der Marel Gijsbert A, Ossendorp Ferry, Van Calenbergh Serge, Kuiper Johan, Habets Kim L L, Saragliadis Anastasios, Saragliadis Athanasios, Florea Bogdan I, Verdoes Martijn, Overkleeft Hermen S

Citation

Hillaert U, Driessen C, van der Marel G, Ossendorp F, Van Calenbergh S, Kuiper J, Habets K, Saragliadis A, Saragliadis A, Florea B, Verdoes M, Overkleeft H. Receptor-mediated targeting of cathepsins in professional antigen presenting cells. Angewandte Chemie (International ed. in English) 2009; 48:1629-32.

Type

Journal Paper/Review (English)

Journal

Angewandte Chemie (International ed. in English) 2009; 48

Publication Date

Jan 1, 2009

Issn Electronic

1521-3773

Pages

1629-32

Brief description/objective

Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.