Glucocorticoids versus glucocorticoids plus cyclophosphamide in eosinophilic granulomatosis with polyangiitis with poor-prognosis factors.

Publication

Glucocorticoids versus glucocorticoids plus cyclophosphamide in eosinophilic granulomatosis with polyangiitis with poor-prognosis factors.

Journal Paper/Review - Nov 16, 2024

Sorin Boris, Papo Matthias, Sinico Renato Alberto, Teixeira Vítor Silvestre, Venhoff Nils, Urban Maria Letizia, Iudici Michele, Mahrhold Juliane, Locatelli Francesco, Cassone Giulia, Schiavon Franco, Seeliger Benjamin, Neumann Thomas, Feder Claudia, Kroegel Claus, Groh Matthieu, Marvisi Chiara, Samson Maxime, Barba Thomas, Jayne David R.W., Troilo Arianna, Thiel Jens, Hellmich Bernhard, Monti Sara, Montecucco Carlomaurizio, Salvarani Carlo, Kahn Jean-Emmanuel, Bonnotte Bernard, Durel Cécile-Audrey, Puéchal Xavier, Mouthon Luc, Guillevin Loic, Emmi Giacomo, Vaglio Augusto, Porcher Raphael, Terrier Benjamin

Citation

Sorin B, Papo M, Sinico R, Teixeira V, Venhoff N, Urban M, Iudici M, Mahrhold J, Locatelli F, Cassone G, Schiavon F, Seeliger B, Neumann T, Feder C, Kroegel C, Groh M, Marvisi C, Samson M, Barba T, Jayne D, Troilo A, Thiel J, Hellmich B, Monti S, Montecucco C, Salvarani C, Kahn J, Bonnotte B, Durel C, Puéchal X, Mouthon L, Guillevin L, Emmi G, Vaglio A, Porcher R, Terrier B. Glucocorticoids versus glucocorticoids plus cyclophosphamide in eosinophilic granulomatosis with polyangiitis with poor-prognosis factors. J Autoimmun 2024; 149:103338.

Type

Journal Paper/Review (English)

Journal

J Autoimmun 2024; 149

Publication Date

Nov 16, 2024

Issn Electronic

1095-9157

Pages

103338

Brief description/objective

Current guidelines suggest treating poor-prognosis eosinophilic granulomatosis with polyangiitis (EGPA) with a combination of glucocorticoids (GCs) plus cyclophosphamide (CYC). However, there is little data to support the need for the addition of CYC. The objective of this study was to compare GCs plus CYC to GCs alone as induction therapy in poor-prognosis EGPA.