Intracranial hemorrhage, outcome, and mortality after intra-arterial therapy for acute ischemic stroke in patients under oral anticoagulants.

Publication

Intracranial hemorrhage, outcome, and mortality after intra-arterial therapy for acute ischemic stroke in patients under oral anticoagulants.

Journal Paper/Review - Oct 6, 2011

De Marchis Gian Marco, Jung Simon, Colucci Giuseppe, Meier Niklaus, Fischer Urs, Weck Anja, Mono Marie-Luise, Galimanis Aekaterini, Mattle Heinrich Paul, Schroth Gerhard, Gralla Jan, Arnold Marcel, Brekenfeld Caspar

Citation

De Marchis G, Jung S, Colucci G, Meier N, Fischer U, Weck A, Mono M, Galimanis A, Mattle H, Schroth G, Gralla J, Arnold M, Brekenfeld C. Intracranial hemorrhage, outcome, and mortality after intra-arterial therapy for acute ischemic stroke in patients under oral anticoagulants. Stroke 2011; 42:3061-6.

Type

Journal Paper/Review (English)

Journal

Stroke 2011; 42

Publication Date

Oct 6, 2011

Issn Electronic

1524-4628

Pages

3061-6

Brief description/objective

Use of intravenous tissue-type plasminogen activator (IV tPA) for acute ischemic stroke is restricted to patients with an international normalized ratio (INR) less than 1.7. However, a recent study showed increased risk of symptomatic intracranial hemorrhage after IV tPA use in patients with oral anticoagulants (OAC) even with an INR less than 1.7. The present study assessed the risk of symptomatic intracranial hemorrhage, clinical outcome, and mortality after intra-arterial therapy (IAT) in patients with and without previous use of OAC.