Diagnostic accuracy of plasma glial fibrillary acidic protein for differentiating intracerebral hemorrhage and cerebral ischemia in patients with symptoms of acute stroke.

Publication

Diagnostic accuracy of plasma glial fibrillary acidic protein for differentiating intracerebral hemorrhage and cerebral ischemia in patients with symptoms of acute stroke.

Journal Paper/Review - Nov 28, 2011

Foerch Christian, Niessner Marion, Back Tobias, Bauerle Michael, De Marchis Gian Marco, Ferbert Andreas, Grehl Holger, Hamann Gerhard F, Jacobs Andreas, Kastrup Andreas, Klimpe Sven, Palm Frederick, Thomalla Götz, Worthmann Hans, Sitzer Matthias, BE FAST Study Group

Citation

Foerch C, Niessner M, Back T, Bauerle M, De Marchis G, Ferbert A, Grehl H, Hamann G, Jacobs A, Kastrup A, Klimpe S, Palm F, Thomalla G, Worthmann H, Sitzer M, BE FAST Study Group. Diagnostic accuracy of plasma glial fibrillary acidic protein for differentiating intracerebral hemorrhage and cerebral ischemia in patients with symptoms of acute stroke. Clin Chem 2011; 58:237-45.

Type

Journal Paper/Review (English)

Journal

Clin Chem 2011; 58

Publication Date

Nov 28, 2011

Issn Electronic

1530-8561

Pages

237-45

Brief description/objective

Glial fibrillary acidic protein (GFAP) is a biomarker candidate indicative of intracerebral hemorrhage (ICH) in patients with symptoms of acute stroke. GFAP is released rapidly in the presence of expanding intracerebral bleeding, whereas a more gradual release occurs in ischemic stroke. In this study the diagnostic accuracy of plasma GFAP was determined in a prospective multicenter approach.