Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation.

Publication

Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation.

Journal Paper/Review - Apr 14, 2022

Polymeris Alexandros A, Helfenstein Fabrice, Benkert Pascal, Aeschbacher Stefanie, Leppert David, Coslovsky Michael, Willemse Eline, Schaedelin Sabine A, Blum Manuel R, Rodondi Nicolas, Reichlin Tobias, Moschovitis Giorgio, Wuerfel Jens, De Marchis Gian Marco, Engelter Stefan T, Lyrer Philippe A, Conen David, Kühne Michael, Osswald Stefan, Bonati Leo H, Kuhle Jens, Swiss-AF investigators

Citation

Polymeris A, Helfenstein F, Benkert P, Aeschbacher S, Leppert D, Coslovsky M, Willemse E, Schaedelin S, Blum M, Rodondi N, Reichlin T, Moschovitis G, Wuerfel J, De Marchis G, Engelter S, Lyrer P, Conen D, Kühne M, Osswald S, Bonati L, Kuhle J, Swiss-AF investigators. Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation. Front Neurosci 2022; 16:819010.

Type

Journal Paper/Review (English)

Journal

Front Neurosci 2022; 16

Publication Date

Apr 14, 2022

Issn Print

1662-4548

Pages

819010

Brief description/objective

Serum neurofilament light chain (sNfL) is increasingly used as a neuroaxonal injury biomarker in the elderly. Besides age, little is known about how other physiological factors like renal function and body mass index (BMI) alter its levels. Here, we investigated the association of estimated glomerular filtration rate (eGFR) and BMI with sNfL in a large sample of elderly patients with atrial fibrillation (AF).