Publication
Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial.
Journal Paper/Review - Dec 19, 2022
Roaldsen Melinda B, Eltoft Agnethe, Wilsgaard Tom, Christensen Hanne, Engelter Stefan T, Indredavik Bent, Jatužis Dalius, Karelis Guntis, Kõrv Janika, Lundström Erik, Petersson Jesper, Putaala Jukka, Søyland Mary-Helen, Tveiten Arnstein, Bivard Andrew, Johnsen Stein Harald, Mazya Michael V, Werring David J, Wu Teddy Y, De Marchis Gian Marco, Robinson Thompson G, Mathiesen Ellisiv B, TWIST Investigators
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Brief description/objective
Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functional outcome in patients with ischaemic wake-up stroke selected using non-contrast CT.