Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial.

Publication

Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial.

Journal Paper/Review - Dec 19, 2022

Roaldsen Melinda B, Eltoft Agnethe, Wilsgaard Tom, Christensen Hanne, Engelter Stefan T, Indredavik Bent, Jatužis Dalius, Karelis Guntis, Kõrv Janika, Lundström Erik, Petersson Jesper, Putaala Jukka, Søyland Mary-Helen, Tveiten Arnstein, Bivard Andrew, Johnsen Stein Harald, Mazya Michael V, Werring David J, Wu Teddy Y, De Marchis Gian Marco, Robinson Thompson G, Mathiesen Ellisiv B, TWIST Investigators

Citation

Roaldsen M, Eltoft A, Wilsgaard T, Christensen H, Engelter S, Indredavik B, Jatužis D, Karelis G, Kõrv J, Lundström E, Petersson J, Putaala J, Søyland M, Tveiten A, Bivard A, Johnsen S, Mazya M, Werring D, Wu T, De Marchis G, Robinson T, Mathiesen E, TWIST Investigators. Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial. Lancet Neurol 2022; 22:117-126.

Type

Journal Paper/Review (English)

Journal

Lancet Neurol 2022; 22

Publication Date

Dec 19, 2022

Issn Electronic

1474-4465

Pages

117-126

Brief description/objective

Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functional outcome in patients with ischaemic wake-up stroke selected using non-contrast CT.