Parameters of the Lyman Model for Calculation of Normal-Tissue Complication Probability: A Systematic Literature Review.

Publication

Parameters of the Lyman Model for Calculation of Normal-Tissue Complication Probability: A Systematic Literature Review.

Journal Paper/Review - Aug 24, 2022

Dennstädt Fabio, Medová Michaela, Putora Paul Martin, Glatzer Markus

Citation

Dennstädt F, Medová M, Putora P, Glatzer M. Parameters of the Lyman Model for Calculation of Normal-Tissue Complication Probability: A Systematic Literature Review. Int J Radiat Oncol Biol Phys 2022; 115:696-706.

Type

Journal Paper/Review (English)

Journal

Int J Radiat Oncol Biol Phys 2022; 115

Publication Date

Aug 24, 2022

Issn Electronic

1879-355X

Pages

696-706

Brief description/objective

The Lyman model is one of the most used radiobiological models for calculation of normal-tissue complication probability (NTCP). Since its introduction in 1985, many authors have published parameter values for the model based on clinical data of different radiotherapeutic situations. This study attempted to collect the entirety of radiobiological parameter sets published to date and provide an overview of the data basis for different variations of the model. Furthermore, it sought to compare the parameter values and calculated NTCPs for selected endpoints with sufficient data available.