Parameters of the Lyman model for calculation of normal tissue complication probability: a systematic literature review.
Journal Paper/Review - Aug 24, 2022
Dennstädt Fabio, Medová Michaela, Putora Paul Martin, Glatzer Markus
The Lyman model is one of the most used radiobiological models for calculation of Normal Tissue Complication Probability (NTCP). Since its introduction in 1985 many authors have published parameter values for the model based on clinical data of different radiotherapeutic situations. We attempted to collect the entirety of radiobiological parameter sets published until now and to provide an overview of the data basis for different variations of the model. Furthermore, we sought to compare the parameter values and calculated NTCPs for selected endpoints with sufficient data available.