Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage.

Publication

Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage.

Journal Paper/Review - Jan 10, 2020

Hostettler Isabel, Werring David J, Galea Ian, Bulters Diederik, Houlden Henry, Muir Keith, Brown Martin M, Lip Gregory Y H, Al-Shahi Salman Rustam, Yousry Tarek A, Cohen Hannah, Jäger H, Shakeshaft Clare, Wilson Duncan, Gaunt Tom, Kazmi Nabila, Ambler Gareth, Morton Matthew J, ĀăąĆĉČĎ Ā ā Ă ă Ą ą Ć ć Ĉ ĉ Ċ ċ Č č Ď ď Đ đ Ē ē Ĕ ĕ Ė ė Ę ę Ě ě Ĝ ĝ Ğ ğ Ġ ġ Ģ ģ Ĥ ĥ Ħ ħ Ĩ ĩ Ī ī Ĭ ĭ Į į İ ı Ĳ ĳ Ĵ ĵ Ķ ķ ĸ Ĺ ĺ Ļ ļ Ľ ľ Ŀ ŀ Ł ł Ń ń Ņ ņ Ň ň ŉ Ŋ ŋ Ō ō Ŏ ŏ Ő ő Œ œ Ŕ ŕ Ŗ ŗ Ř ř Ś ś Ŝ ŝ Ş ş Š š Ţ ţ Ť ť Ŧ ŧ Ũ ũ Ū ū Ŭ ŭ Ů ů Ű ű Ų ų Ŵ ŵ Ŷ ŷ Ÿ Ź ź Ż ż Ž ž ſ

Citation

Hostettler I, Werring D, Galea I, Bulters D, Houlden H, Muir K, Brown M, Lip G, Al-Shahi Salman R, Yousry T, Cohen H, Jäger H, Shakeshaft C, Wilson D, Gaunt T, Kazmi N, Ambler G, Morton M, ĀăąĆĉČĎ Ā. Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage. J Neurol Neurosurg Psychiatry 2020; 91:298-304.

Type

Journal Paper/Review (English)

Journal

J Neurol Neurosurg Psychiatry 2020; 91

Publication Date

Jan 10, 2020

Issn Electronic

1468-330X

Pages

298-304

Brief description/objective

Haptoglobin is a haemoglobin-scavenging protein that binds and neutralises free haemoglobin and modulates inflammation and endothelial progenitor cell function. A gene copy number variation (CNV) generates HP1 and HP2 alleles, while the single-nucleotide polymorphism rs2000999 influences their levels. The HP1 allele is hypothesised to improve outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH). We investigated the associations of the CNV genotype and rs2000999 with haematoma volume, perihaematomal oedema (PHO) volume, functional outcome and mortality after ICH.