Publication

Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage.

Journal Paper/Review - Jan 10, 2020

Units
PubMed
Doi
Contact

Citation
Hostettler I, Werring D, Galea I, Bulters D, Houlden H, Muir K, Brown M, Lip G, Al-Shahi Salman R, Yousry T, Cohen H, Jäger H, Shakeshaft C, Wilson D, Gaunt T, Kazmi N, Ambler G, Morton M, ĀăąĆĉČĎ Ā. Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage. J Neurol Neurosurg Psychiatry 2020; 91:298-304.
Type
Journal Paper/Review (English)
Journal
J Neurol Neurosurg Psychiatry 2020; 91
Publication Date
Jan 10, 2020
Issn Electronic
1468-330X
Pages
298-304
Brief description/objective

Haptoglobin is a haemoglobin-scavenging protein that binds and neutralises free haemoglobin and modulates inflammation and endothelial progenitor cell function. A gene copy number variation (CNV) generates HP1 and HP2 alleles, while the single-nucleotide polymorphism rs2000999 influences their levels. The HP1 allele is hypothesised to improve outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH). We investigated the associations of the CNV genotype and rs2000999 with haematoma volume, perihaematomal oedema (PHO) volume, functional outcome and mortality after ICH.