ESTRO ACROP guidelines for target volume definition in the thoracic radiation treatment of small cell lung cancer
Journal Paper/Review - Jul 13, 2020
Le Pechoux Cecile, Van Houtte Paul, Hurkmans Coen, Lievens Yolande, Peeters Stephanie, Dziadiuszko Rafal, Pöttgen Christoph, Belderbos Jose, Geets Xavier, Ricardi Umberto, De Ruysscher Dirk, Slotman Ben, Putora Paul Martin, Manapov Farkhad, McDonald Fiona, Ramella Sara, Faivre-Finn Corinne, Nestle Ursula
Radiotherapy (RT) plays a major role in the treatment of small cell lung cancer (SCLC). Therefore, the ACROP committee was asked by ESTRO to provide recommendations on target volume delineation for standard clinical scenarios in definitive (chemo)-radiotherapy (CRT), adjuvant RT for stages I-III SCLC and consolidation thoracic RT for stage IV disease. The aim of these guidelines is to standardise and optimise the process of RT treatment planning for clinical practice and prospective studies. The process for the development of the guidelines included the evaluation of a structured questionnaire followed by a consensus discussion, voting and writing process within the committee. Firstly, we provide recommendations for both the imaging to be performed as part of the diagnostic work-up and for the RT planning process. Secondly, recommendations are made for target volume delineation including delineation of the primary gross tumour volume (GTV) and lymph node GTV and clinical tumour volume (CTV) expansion in the context of definitive and adjuvant RT. With regard to internal target volume (ITV) and planning target volume (PTV) definitions, we make recommendations about the management of geometric uncertainties and target motion. Finally, we provide our opinions on organ at risk (OAR) delineation and organisational issues to be considered.