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ESTRO ACROP guidelines for target volume definition in the thoracic radiation treatment of small cell lung cancer

Journal Paper/Review - Jul 13, 2020

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Citation
Le Pechoux C, Van Houtte P, Hurkmans C, Lievens Y, Peeters S, Dziadiuszko R, Pöttgen C, Belderbos J, Geets X, Ricardi U, De Ruysscher D, Slotman B, Putora P, Manapov F, McDonald F, Ramella S, Faivre-Finn C, Nestle U. ESTRO ACROP guidelines for target volume definition in the thoracic radiation treatment of small cell lung cancer. Radiother Oncol 2020; 152:89-95.
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Journal Paper/Review (English)
Journal
Radiother Oncol 2020; 152
Publication Date
Jul 13, 2020
Issn Print
Issn Electronic
1879-0887
Pages
89-95
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Brief description/objective

Radiotherapy (RT) plays a major role in the treatment of small cell lung cancer (SCLC). Therefore, the ACROP committee was asked by ESTRO to provide recommendations on target volume delineation for standard clinical scenarios in definitive (chemo)-radiotherapy (CRT), adjuvant RT for stages I-III SCLC and consolidation thoracic RT for stage IV disease. The aim of these guidelines is to standardise and optimise the process of RT treatment planning for clinical practice and prospective studies. The process for the development of the guidelines included the evaluation of a structured questionnaire followed by a consensus discussion, voting and writing process within the committee. Firstly, we provide recommendations for both the imaging to be performed as part of the diagnostic work-up and for the RT planning process. Secondly, recommendations are made for target volume delineation including delineation of the primary gross tumour volume (GTV) and lymph node GTV and clinical tumour volume (CTV) expansion in the context of definitive and adjuvant RT. With regard to internal target volume (ITV) and planning target volume (PTV) definitions, we make recommendations about the management of geometric uncertainties and target motion. Finally, we provide our opinions on organ at risk (OAR) delineation and organisational issues to be considered.