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Laryngopharyngeal reflux in chronic obstructive pulmonary disease - a multi-centre study

Journal Paper/Review - Aug 21, 2020

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Citation
Sanchez J, Schumann D, Karakioulaki M, Papakonstantinou E, Rassouli F, Frasnelli M, Brutsche M, Tamm M, Stolz D. Laryngopharyngeal reflux in chronic obstructive pulmonary disease - a multi-centre study. Respir Res 2020; 21:220.
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Journal Paper/Review (English)
Journal
Respir Res 2020; 21
Publication Date
Aug 21, 2020
Issn Print
Issn Electronic
1465-993X
Pages
220
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Brief description/objective

Reflux of gastric content has been associated with recurrent exacerbations of chronic obstructive pulmonary disease (COPD). We aimed to assess the prevalence of laryngopharyngeal reflux (LPR) in COPD and if LPR is a contributing factor to clinically relevant outcomes in COPD. We evaluated a total of 193 COPD patients (GOLD I-IV) with a 24-h laryngo-pharyngeal pΗ-monitor. LPR was observed in 65.8% of COPD patients and it was not significantly associated with clinically relevant outcomes of COPD. Treatment with PPI significantly decreased the upright RYAN score (p = 0.047) without improving lung function. Furthermore, the presence or severity of LPR cannot be diagnosed based solely on symptoms and questionnaires.