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Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland

Journal Paper/Review - Jul 13, 2020

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Citation
Coste A, Kritikos A, Li J, Khanna N, Goldenberger D, Garzoni C, Zehnder C, Boggian K, Neofytos D, Riat A, Bachmann D, Sanglard D, Lamoth F, Fungal Infection Network of Switzerland (FUNGINOS). Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland. Infection 2020
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Journal Paper/Review (English)
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Infection 2020
Publication Date
Jul 13, 2020
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1439-0973
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Brief description/objective

Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.