Publication

Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland

Journal Paper/Review - Jul 13, 2020

Units
PubMed
Doi

Citation
Coste A, Lamoth F, Sanglard D, Bachmann D, Riat A, Neofytos D, Boggian K, Zehnder C, Garzoni C, Goldenberger D, Khanna N, Li J, Kritikos A, Fungal Infection Network of Switzerland (FUNGINOS). Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland. Infection 2020
Type
Journal Paper/Review (English)
Journal
Infection 2020
Publication Date
Jul 13, 2020
Issn Electronic
1439-0973
Brief description/objective

Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.