Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

Publication

Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

Journal Paper/Review - Oct 30, 2009

Mitchell James R, Hoeijmakers Jan H J, IJzermans Jan N M, van IJcken Wilfred, de Jong Marion, Müller Cristina, Forrer Flavio, Chu Timothy, van den Engel Sandra, Goemaere Natascha, van de Ven Marieke, Brand Karl, Verweij Mariëlle, de Bruin Ron W F

Citation

Mitchell J, Hoeijmakers J, IJzermans J, van IJcken W, de Jong M, Müller C, Forrer F, Chu T, van den Engel S, Goemaere N, van de Ven M, Brand K, Verweij M, de Bruin R. Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice. Aging Cell 2009; 9:40-53.

Type

Journal Paper/Review (English)

Journal

Aging Cell 2009; 9

Publication Date

Oct 30, 2009

Issn Electronic

1474-9726

Pages

40-53

Brief description/objective

Dietary restriction (DR) extends lifespan and increases resistance to multiple forms of stress, including ischemia reperfusion injury to the brain and heart in rodents. While maximal effects on lifespan require long-term restriction, the kinetics of onset of benefits against acute stress is not known. Here, we show that 2-4 weeks of 30% DR improved survival and kidney function following renal ischemia reperfusion injury in mice. Brief periods of water-only fasting were similarly effective at protecting against ischemic damage. Significant protection occurred within 1 day, persisted for several days beyond the fasting period and extended to another organ, the liver. Protection by both short-term DR and fasting correlated with improved insulin sensitivity, increased expression of markers of antioxidant defense and reduced expression of markers of inflammation and insulin/insulin-like growth factor-1 signaling. Unbiased transcriptional profiling of kidneys from mice subject to short-term DR or fasting revealed a significant enrichment of signature genes of long-term DR. These data demonstrate that brief periods of reduced food intake, including short-term daily restriction and fasting, can increase resistance to ischemia reperfusion injury in rodents and suggest a rapid onset of benefits of DR in mammals.