Publication

Serum leptin is associated with serum uric acid concentrations in humans

Journal Paper/Review - Jun 1, 1999

Units
PubMed

Citation
Schultes B, Peters A, Kern W, Beyer J, Pfützner A. Serum leptin is associated with serum uric acid concentrations in humans. Metabolism: clinical and experimental 1999; 48:677-80.
Type
Journal Paper/Review (English)
Journal
Metabolism: clinical and experimental 1999; 48
Publication Date
Jun 1, 1999
Issn Print
0026-0495
Pages
677-80
Brief description/objective

This cross-sectional study aimed to evaluate the relationship between leptin and the cluster of abnormalities often referred to as the metabolic syndrome. The serum leptin concentration, body mass index (BMI), percent body fat, total fat mass (FM), waist and hip circumference, waist to hip ratio (WHR), prevalence of hypertension, and triglyceride (TG), lipoprotein, and uric acid concentration were determined in 86 type 2 diabetic (n = 59) and healthy (n = 27) subjects. Multiple regression analyses showed that the estimates of total body obesity (BMI, percent body fat, and total FM), sex, and serum uric acid concentration are independently associated with the serum leptin concentration. The finding of a positive correlation between serum leptin and uric acid levels suggests that leptin could be a pathogenic factor responsible for hyperuricemia in obesity.