Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma.

Publication

Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma.

Journal Paper/Review - Sep 6, 2018

Plath Michaela, Broglie Martina A, Förbs Diana, Stoeckli Sandro J, Jochum Wolfram

Citation

Plath M, Broglie M, Förbs D, Stoeckli S, Jochum W. Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma. J Otolaryngol Head Neck Surg 2018; 47:53.

Type

Journal Paper/Review (English)

Journal

J Otolaryngol Head Neck Surg 2018; 47

Publication Date

Sep 6, 2018

Issn Electronic

1916-0216

Brief description/objective

Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has an improved outcome and may allow for treatment de-escalation. High-risk HPV (HR-HPV) infection is associated with deregulated expression of the cell cycle-associated proteins p16, pRB, cyclin D1 and p53. The objective of this study was to assess cell cycle proteins as potential surrogate markers for HR-HPV DNA testing to identify OPSCC with favorable prognosis after resection.