Publication

Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings

Journal Paper/Review - Feb 21, 2019

Units
PubMed
Doi

Citation
Alix J, Nandedkar S, Stålberg E, Barkhaus P, Furtula J, van Dijk J, Baldinger R, Costa J, Otto M, Sandberg A, Schrooten M, Omer T, Moglia C, Neuwirth C, Gelder L, Burkhardt C, Castro J, de Carvalho M, Gawel M, Goedee S, Grosskreutz J, Lenglet T, Weber M. Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings. Clin Neurophysiol 2019; 130:666-674.
Type
Journal Paper/Review (English)
Journal
Clin Neurophysiol 2019; 130
Publication Date
Feb 21, 2019
Issn Electronic
1872-8952
Pages
666-674
Brief description/objective

OBJECTIVE
The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject "round robin" and multi-centre settings.

METHODS
Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Intra/inter-rater data were provided by 5 centres, 1 centre provided only intra-rater data. Intra/inter-rater variability was assessed using the coefficient of variation (COV), Bland-Altman plots, bias and 95% limits of agreement.

RESULTS
In the round-robin assessment intra-rater COVs for MUSIX ranged from 7.8% to 28.4%. Inter-rater variability was between 7.8% and 16.2%. Prior experience did not impact on MUSIX values. In the multi-centre study MUSIX was more consistent than the MUNIX. Abductor hallucis was the least reliable muscle.

CONCLUSIONS
The MUSIX is a reliable neurophysiological biomarker of reinnervation.

SIGNIFICANCE
MUSIX could provide insights into the pathophysiology of a range of neuromuscular disorders, providing a quantitative biomarker of reinnervation.