Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study
Journal Paper/Review - Aug 12, 2018
Schreiber Peter W, Bischoff-Ferrari Heike A, Boggian Katia, Van Delden Christian, Enriquez Natalia, Fehr Thomas, Garzoni Christian, Hirsch Hans H, Hirzel Cédric, Manuel Oriol, Meylan Pascal, Saleh Lanja, Maja Weisser, Mueller Nicolas J, Swiss Transplant Cohort Study (STCS)
Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency (25-OH vitamin D [25-OHD] < 50nmol/l) and no deficiency (25-OHD ≥ 50nmol/l) in incident infections after liver transplantation.
In 135 liver transplant recipients blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the STCS database. Poisson regression was applied to address associations between vitamin D status and incident infections.
Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant (IRR 1.52, 95% CI 1.08-2.15, P=0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P=0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders.
Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections. This article is protected by copyright. All rights reserved.