Publication

Immunopathogenesis of atherosclerosis

Journal Paper/Review - Aug 1, 2004

Units
PubMed
Doi

Citation
Ludewig B, Krebs P, Scandella E. Immunopathogenesis of atherosclerosis. Journal of leukocyte biology 2004; 76:300-6.
Type
Journal Paper/Review (English)
Journal
Journal of leukocyte biology 2004; 76
Publication Date
Aug 1, 2004
Issn Print
0741-5400
Pages
300-6
Brief description/objective

Recent clinical studies indicate that the number of microbial infections (the "pathogen burden") critically determines the development and progression of atherosclerotic disease. Viruses or bacteria with a specific tropism for cells of the vascular wall may contribute to the initial vascular injury via direct cytopathic effects or via the induction of genuine autoimmune responses. Immunopathological processes such as molecular mimicry, epitope spreading, or bystander activation of self-reactive lymphocytes most likely fuel the chronic inflammatory process in the vascular wall. Recognition of atherogenesis as a pathogen-driven, immunopathological process makes this disease amenable to new treatment strategies such as vaccination or immunomodulation.