Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization

Publication

Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization

Journal Paper/Review - Dec 12, 2013

Fellmann Jonas, Weisert Jan U, Soltermann Alex, Morand Grégoire, Morra Laura, Moch Holger, Huber Gerhard, Probst Rudolf

Citation

Fellmann J, Weisert J, Soltermann A, Morand G, Morra L, Moch H, Huber G, Probst R. Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization. Head & neck 2013; 36:1562-6.

Type

Journal Paper/Review (English)

Journal

Head & neck 2013; 36

Publication Date

Dec 12, 2013

Issn Electronic

1097-0347

Pages

1562-6

Brief description/objective

BACKGROUND
Helicobacter pylori is known to cause gastric cancer. Presence and carcinogenicity in the upper aerodigestive system is doubtful. This study examined the prevalence of Helicobacter pylori and related factors in biopsies from the upper aerodigestive tract (UADT) in patients with gastric colonization by Helicobacter pylori.

METHODS
In a case series study, 26 patients with histopathologically confirmed gastric colonization were identified. A polymerase chain reaction (PCR) was performed on matched formalin-fixed and paraffin-embedded tissues of the stomach and the oral cavity, pharynx, or larynx.

RESULTS
Helicobacter pylori was found in 38% of the samples from the oral cavity, pharynx, and larynx. An association with malignancies in these regions or possible risk factors, such as age, smoking, or alcohol, was not found.

CONCLUSION
The upper aerodigestive system seems to be an additional reservoir in a significant percentage of patients presenting with Helicobacter pylori gastritis.